Mitochondrial amidoxime reducing component 1

MTARC1
Identifiers
Aliases	MTARC1, MOSC1, mitochondrial amidoxime reducing component 1, MARC1
External IDs	OMIM: 614126; MGI: 1913362; HomoloGene: 129604; GeneCards: MTARC1; OMA:MTARC1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	220,819,659 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	184,543,510 bp
RNA expression pattern
	Top expressed in
	adipose tissue; ; abdominal fat; ; right lobe of liver; ; right lobe of thyroid gland; ; subcutaneous adipose tissue; ; left lobe of thyroid gland; ; monocyte; ; mucosa of transverse colon; ; parotid gland; ; ventricular zone;
	Top expressed in
	left lobe of liver; ; yolk sac; ; white adipose tissue; ; sexually immature organism; ; mammary gland; ; lumbar subsegment of spinal cord; ; lumbar spinal ganglion; ; brown adipose tissue; ; subcutaneous adipose tissue; ; tunica adventitia of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	molybdopterin cofactor binding; molybdenum ion binding; oxidoreductase activity; pyridoxal phosphate binding; nitrate reductase activity; catalytic activity;
Cellular component	integral component of membrane; membrane; mitochondrion; mitochondrial outer membrane;
Biological process	detoxification of nitrogen compound; nitrate metabolic process; xenobiotic metabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	64757
	66112
	ENSG00000186205
	ENSMUSG00000026621
	Q5VT66
	Q9CW42
	NM_022746
	NM_001081361; NM_001290273
	NP_073583
	NP_001277202
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial amidoxime-reducing component 1 (also known as MOCO sulphurase C-terminal domain containing 1, MOSC1 or MARC1) is an enzyme which in humans is encoded by the MOSC1 gene.^[5]^[6]

MOCO stands for molybdenum cofactor.

MOSC1 has been reported to reduce amidoximes to amidines.^[7]^[8]

Genetic variation in MARC1 has been reported to be associated with lower blood cholesterol levels, blood liver enzyme levels, reduced liver fat and protection from cirrhosis suggesting that MARC1 deficiency may protect against liver disease.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186205 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026621 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anantharaman V, Aravind L (January 2002). "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases". FEMS Microbiol. Lett. 207 (1): 55–61. doi:10.1016/S0378-1097(01)00515-8. PMID 11886751.
^ "Entrez Gene: Mitochondrial amidoxime reducing component 1". Retrieved 2016-03-03.
^ Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B (November 2006). "Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme". J. Biol. Chem. 281 (46): 34796–802. doi:10.1074/jbc.M607697200. PMID 16973608.
^ Gruenewald S, Wahl B, Bittner F, Hungeling H, Kanzow S, Kotthaus J, Schwering U, Mendel RR, Clement B (December 2008). "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs". J. Med. Chem. 51 (24): 8173–7. doi:10.1021/jm8010417. PMID 19053771.
^ Kathiresan, Sekar; Gabriel, Stacey; Denny, Joshua; Daly, Mark; Saleheen, Danish; Danesh, John; Gupta, Namrata; Erdmann, Jeanette; Baber, Usman (2019-03-31). "A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease". bioRxiv: 594523. doi:10.1101/594523.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186205 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026621 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11886751-5] Anantharaman V, Aravind L (January 2002). "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases". FEMS Microbiol. Lett. 207 (1): 55–61. doi:10.1016/S0378-1097(01)00515-8. PMID 11886751.

[entrez-6] "Entrez Gene: Mitochondrial amidoxime reducing component 1". Retrieved 2016-03-03.

[pmid16973608-7] Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B (November 2006). "Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme". J. Biol. Chem. 281 (46): 34796–802. doi:10.1074/jbc.M607697200. PMID 16973608.

[pmid19053771-8] Gruenewald S, Wahl B, Bittner F, Hungeling H, Kanzow S, Kotthaus J, Schwering U, Mendel RR, Clement B (December 2008). "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs". J. Med. Chem. 51 (24): 8173–7. doi:10.1021/jm8010417. PMID 19053771.

[9] Kathiresan, Sekar; Gabriel, Stacey; Denny, Joshua; Daly, Mark; Saleheen, Danish; Danesh, John; Gupta, Namrata; Erdmann, Jeanette; Baber, Usman (2019-03-31). "A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease". bioRxiv: 594523. doi:10.1101/594523.

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See also

References