From Wikipedia, the free encyclopedia
Mitochondrial amidoxime-reducing component 1 (also known as MOCO sulphurase C-terminal domain containing 1 , MOSC1 or MARC1 ) is an enzyme which in humans is encoded by the MOSC1 gene .[ 5] [ 6]
MOCO stands for mo lybdenum co factor.
MOSC1 has been reported to reduce amidoximes to amidines .[ 7] [ 8]
Genetic variation in MARC1 has been reported to be associated with lower blood cholesterol levels, blood liver enzyme levels, reduced liver fat and protection from cirrhosis suggesting that MARC1 deficiency may protect against liver disease.[ 9]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000186205 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026621 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Anantharaman V, Aravind L (January 2002). "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases". FEMS Microbiol. Lett . 207 (1): 55–61. doi :10.1016/S0378-1097(01)00515-8 . PMID 11886751 .
^
"Entrez Gene: Mitochondrial amidoxime reducing component 1" . Retrieved 2016-03-03 .
^ Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B (November 2006). "Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme" . J. Biol. Chem . 281 (46): 34796–802. doi :10.1074/jbc.M607697200 . PMID 16973608 .
^ Gruenewald S, Wahl B, Bittner F, Hungeling H, Kanzow S, Kotthaus J, Schwering U, Mendel RR, Clement B (December 2008). "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs". J. Med. Chem . 51 (24): 8173–7. doi :10.1021/jm8010417 . PMID 19053771 .
^ Kathiresan, Sekar; Gabriel, Stacey; Denny, Joshua; Daly, Mark; Saleheen, Danish; Danesh, John; Gupta, Namrata; Erdmann, Jeanette; Baber, Usman (2019-03-31). "A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease" . bioRxiv : 594523. doi :10.1101/594523 .