PILRB

PILRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NFC, 4NFD
Identifiers
Aliases	PILRB, FDFACT1, FDFACT2, paired immunoglobin-like type 2 receptor beta, paired immunoglobin like type 2 receptor beta
External IDs	OMIM: 605342; MGI: 2450532; HomoloGene: 114502; GeneCards: PILRB; OMA:PILRB - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,367,831 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,856,368 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right uterine tube; ; pituitary gland; ; right hemisphere of cerebellum; ; anterior pituitary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; granulocyte; ; spleen;
	Top expressed in
	granulocyte; ; spleen; ; bone marrow; ; embryo; ; jejunum; ; embryo; ; liver; ; ileum; ; colon; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MHC class I protein binding; protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane;
Biological process	activation of transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of immune response;
	Sources:Amigo / QuickGO
Orthologs
	29990
	170741
	ENSG00000121716
	ENSMUSG00000066684
	Q9UKJ0
	Q2YFS2
	NM_178238; NM_013440; NM_175047; NM_001371931
	NM_133209
	NP_839956; NP_001358860
	NP_573472
	Wikidata
View/Edit Human	View/Edit Mouse

Paired immunoglobulin-like type 2 receptor beta is a protein that in humans is encoded by the PILRB gene.^[5]^[6]

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121716 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066684 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mousseau DD, Banville D, L'Abbe D, Bouchard P, Shen SH (Mar 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J Biol Chem. 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. PMID 10660620.
^ ^a ^b "Entrez Gene: PILRB paired immunoglobin-like type 2 receptor beta".

Fournier N; Chalus L; Durand I; et al. (2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. 165 (3): 1197–209. doi:10.4049/jimmunol.165.3.1197. PMID 10903717. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lehner B; Semple JI; Brown SE; et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Zhu YX; Benn S; Li ZH; et al. (2004). "The SH3–SAM Adaptor HACS1 is Up-regulated in B Cell Activation Signaling Cascades". J. Exp. Med. 200 (6): 737–47. doi:10.1084/jem.20031816. PMC 2211965. PMID 15381729. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Wan D; Gong Y; Qin W; et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Wilson MD; Cheung J; Martindale DW; et al. (2006). "Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes". Physiol. Genomics. 27 (3): 201–18. doi:10.1152/physiolgenomics.00284.2005. PMID 16926269. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121716 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066684 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10660620-5] Mousseau DD, Banville D, L'Abbe D, Bouchard P, Shen SH (Mar 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J Biol Chem. 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. PMID 10660620.

[entrez-6] "Entrez Gene: PILRB paired immunoglobin-like type 2 receptor beta".

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References

Further reading