CSRP2

CSRP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CU8
Identifiers
Aliases	CSRP2, CRP2, LMO5, SmLIM, cysteine and glycine rich protein 2
External IDs	OMIM: 601871; MGI: 1202907; HomoloGene: 111061; GeneCards: CSRP2; OMA:CSRP2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	76,879,023 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	110,775,483 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ganglionic eminence; ; tibial arteries; ; right coronary artery; ; mucosa of paranasal sinus; ; parietal pleura; ; gingival epithelium; ; gastric mucosa; ; optic nerve;
	Top expressed in
	ascending aorta; ; aortic valve; ; tunica media of zone of aorta; ; umbilical cord; ; endocardial cushion; ; atrium; ; mandibular prominence; ; external carotid artery; ; atrioventricular valve; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; molecular function; structural constituent of muscle; actinin binding;
Cellular component	nucleus; focal adhesion; cytoplasm; Z discdkac;
Biological process	multicellular organism development; cell differentiation; actin cytoskeleton organization; sarcomere organization; muscle tissue development;
	Sources:Amigo / QuickGO
Orthologs
	1466
	13008
	ENSG00000175183
	ENSMUSG00000020186
	Q16527
	P97314
	NM_001300965; NM_001321
	NM_007792
	NP_001287894; NP_001312
	NP_031818
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine and glycine-rich protein 2 is a protein that in humans is encoded by the CSRP2 gene.^[5]^[6]^[7]

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175183 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020186 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
^ Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.
^ ^a ^b "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".

External links

Human CSRP2 genome location and CSRP2 gene details page in the UCSC Genome Browser.

Jain MK; Fujita KP; Hsieh CM; et al. (1996). "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells". J. Biol. Chem. 271 (17): 10194–9. doi:10.1074/jbc.271.17.10194. PMID 8626582. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Karim MA; Ohta K; Egashira M; et al. (1997). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Weiskirchen R, Gressner AM (2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochem. Biophys. Res. Commun. 274 (3): 655–63. doi:10.1006/bbrc.2000.3187. PMID 10924333.
Weiskirchen R; Moser M; Weiskirchen S; et al. (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. doi:10.1042/0264-6021:3590485. PMC 1222169. PMID 11672422. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Wang M, Hu Y, Shima I, Stearns ME (2003). "IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines". Cancer Biol. Ther. 1 (5): 556–63. doi:10.4161/cbt.1.5.222. PMID 12496489.
Stearns ME, Wang M, Hu Y, Garcia FU (2004). "Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines". Mol. Cancer Res. 1 (9): 631–42. PMID 12861049.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175183 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020186 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7499425-5] Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.

[pmid9286703-6] Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.

[entrez-7] "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".

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References

External links

Further reading