Galectin-7

LGALS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UW5, 2GAL, 4GAL, 1BKZ, 4UW4, 3ZXE, 3GAL, 3ZXF, 4UW6, 4XBQ, 5GAL, 4UW3, 5H9S, 4Y26, 5H9Q
Identifiers
Aliases	LGALS7, GAL7, LGALS7A, galectin 7
External IDs	OMIM: 600615; MGI: 1316742; HomoloGene: 100509; GeneCards: LGALS7; OMA:LGALS7 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.2 Start 38,770,968 bp End 38,773,517 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B1 Start 28,563,278 bp End 28,565,709 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg olfactory zone of nasal mucosa gonad testicle vagina minor salivary glands ectocervix right lung spleen Top expressed in lip esophagus skin of external ear superior surface of tongue skin of abdomen skin of back umbilical cord epidermis hair follicle condyle More reference expression data BioGPS n/a
Gene ontology Molecular function carbohydrate binding Cellular component cytoplasm extracellular region extracellular exosome nucleus extracellular space Biological process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3963 16858 Ensembl ENSG00000283082 ENSG00000205076 ENSMUSG00000053522 UniProt P47929 O54974 RefSeq (mRNA) NM_002307 NM_008496 RefSeq (protein) NP_002298 NP_001035972 n/a Location (UCSC) Chr 19: 38.77 – 38.77 Mb Chr 7: 28.56 – 28.57 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Galectin-7 is a protein that in humans is encoded by the LGALS7 gene.

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and suprabasal layers). It is moderately repressed by retinoic acid. The protein was found mainly in stratified squamous epithelium. The antigen localized to basal keratinocytes, although it was also found, albeit at lower levels, in the suprabasal layers where it concentrated to areas of cell-to-cell contact. The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell–cell and/or cell–matrix interactions necessary for normal growth control.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Polyak K, Xia Y, Zweier JL, et al. (1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. doi:10.1038/38525. PMID 9305847.
• Magnaldo T, Fowlis D, Darmon M (1998). "Galectin-7, a marker of all types of stratified epithelia". Differentiation. 63 (3): 159–68. doi:10.1046/j.1432-0436.1998.6330159.x. PMID 9697310.
• Leonidas DD, Vatzaki EH, Vorum H, et al. (1998). "Structural basis for the recognition of carbohydrates by human galectin-7". Biochemistry. 37 (40): 13930–40. doi:10.1021/bi981056x. PMID 9760227.
• Bernerd F, Sarasin A, Magnaldo T (1999). "Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11329–34. doi:10.1073/pnas.96.20.11329. PMC 18033. PMID 10500176.
• Kuwabara I, Kuwabara Y, Yang RY, et al. (2002). "Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release". J. Biol. Chem. 277 (5): 3487–97. doi:10.1074/jbc.M109360200. PMID 11706006.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cao Z, Said N, Wu HK, et al. (2003). "Galectin-7 as a potential mediator of corneal epithelial cell migration". Arch. Ophthalmol. 121 (1): 82–6. doi:10.1001/archopht.121.1.82. PMID 12523890.
• Kopitz J, André S, von Reitzenstein C, et al. (2003). "Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells". Oncogene. 22 (40): 6277–88. doi:10.1038/sj.onc.1206631. PMID 13679866.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Saussez S, Cucu DR, Decaestecker C, et al. (2006). "Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer". Ann. Surg. Oncol. 13 (7): 999–1009. doi:10.1245/ASO.2006.08.033. PMID 16788763.