EBAG9

EBAG9
Identifiers
Aliases	EBAG9, EB9, PDAF, estrogen receptor binding site associated, antigen, 9, estrogen receptor binding site associated antigen 9
External IDs	OMIM: 605772; MGI: 1859920; HomoloGene: 3107; GeneCards: EBAG9; OMA:EBAG9 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	109,565,996 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	44,504,911 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; corpus epididymis; ; caput epididymis; ; endothelial cell; ; Achilles tendon; ; kidney tubule; ; tail of epididymis; ; Brodmann area 23; ; Epithelium of choroid plexus; ; glomerulus;
	Top expressed in
	seminal vesicula; ; parotid gland; ; submandibular gland; ; atrioventricular valve; ; tail of embryo; ; triceps brachii muscle; ; endocardial cushion; ; genital tubercle; ; migratory enteric neural crest cell; ; ascending aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activator activity involved in apoptotic process;
Cellular component	integral component of membrane; Golgi apparatus; secretory granule; membrane; Golgi membrane;
Biological process	regulation of cell growth; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9166
	55960
	ENSG00000147654
	ENSMUSG00000022339
	O00559
	Q9D0V7
	NM_198120; NM_001278938; NM_004215
	NM_019480; NM_001357690; NM_001357691
	NP_001265867; NP_004206; NP_936056
	NP_062353; NP_001344619; NP_001344620
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-binding cancer antigen expressed on SiSo cells is a protein that in humans is encoded by the EBAG9 gene.

This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147654 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022339 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EBAG9 estrogen receptor binding site associated, antigen, 9".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Watanabe T; Inoue S; Hiroi H; et al. (1998). "Isolation of Estrogen-Responsive Genes with a CpG Island Library". Mol. Cell. Biol. 18 (1): 442–9. doi:10.1128/mcb.18.1.442. PMC 121513. PMID 9418891. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Nakashima M, Sonoda K, Watanabe T (1999). "Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1". Nat. Med. 5 (8): 938–42. doi:10.1038/11383. PMID 10426319.
Ikeda K; Sato M; Tsutsumi O; et al. (2000). "Promoter analysis and chromosomal mapping of human EBAG9 gene". Biochem. Biophys. Res. Commun. 273 (2): 654–60. doi:10.1006/bbrc.2000.2920. PMID 10873660. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ohshima K; Nakashima M; Sonoda K; et al. (2001). "Expression of RCAS1 and FasL in human trophoblasts and uterine glands during pregnancy: the possible role in immune privilege". Clin. Exp. Immunol. 123 (3): 481–6. doi:10.1046/j.1365-2249.2001.01461.x. PMC 1906005. PMID 11298137. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Matsushima T; Nakashima M; Oshima K; et al. (2001). "Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells". Blood. 98 (2): 313–21. doi:10.1182/blood.V98.2.313. PMID 11435298. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Tsuneizumi M; Emi M; Nagai H; et al. (2002). "Overrepresentation of the EBAG9 gene at 8q23 associated with early-stage breast cancers". Clin. Cancer Res. 7 (11): 3526–32. PMID 11705872. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Umeoka K; Sanno N; Oyama K; et al. (2002). "Immunohistochemical analysis of RCAS1 in human pituitary adenomas". Mod. Pathol. 14 (12): 1232–6. doi:10.1038/modpathol.3880467. PMID 11743045. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Hiraoka K; Hida Y; Miyamoto M; et al. (2002). "High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker". Int. J. Cancer. 99 (3): 418–23. doi:10.1002/ijc.10381. PMID 11992411. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rousseau J; Têtu B; Caron D; et al. (2002). "RCAS1 is associated with ductal breast cancer progression". Biochem. Biophys. Res. Commun. 293 (5): 1544–9. doi:10.1016/S0006-291X(02)00401-1. PMID 12054692. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Oizumi S; Yamazaki K; Nakashima M; et al. (2002). "RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung". Oncology. 62 (4): 333–9. doi:10.1159/000065065. PMID 12138241. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Engelsberg A; Hermosilla R; Karsten U; et al. (2003). "The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens". J. Biol. Chem. 278 (25): 22998–3007. doi:10.1074/jbc.M301361200. PMID 12672804. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Abe Y; Ohshima K; Nakashima M; et al. (2003). "Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis". Int. J. Hematol. 77 (4): 359–63. doi:10.1007/BF02982644. PMID 12774924. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Takahashi S; Urano T; Tsuchiya F; et al. (2003). "EBAG9/RCAS1 expression and its prognostic significance in prostatic cancer". Int. J. Cancer. 106 (3): 310–5. doi:10.1002/ijc.11205. PMID 12845666. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Sonoda K; Miyamoto S; Hirakawa T; et al. (2003). "Association between RCAS1 expression and clinical outcome in uterine endometrial cancer". Br. J. Cancer. 89 (3): 546–51. doi:10.1038/sj.bjc.6601126. PMC 2394364. PMID 12888828. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Leelawat K; Watanabe T; Nakajima M; et al. (2003). "Upregulation of tumour associated antigen RCAS1 is implicated in high stages of colorectal cancer". J. Clin. Pathol. 56 (10): 764–8. doi:10.1136/jcp.56.10.764. PMC 1770069. PMID 14514780. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ikeguchi M; Ohoro S; Maeda Y; et al. (2004). "Protein and gene expression of tumor-associated antigen RCAS1 in esophageal squamous cell carcinoma". Oncol. Rep. 10 (6): 1891–4. doi:10.3892/or.10.6.1891. PMID 14534714. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ikeguchi M, Hirooka Y, Kaibara N (2004). "Gene and protein expression of RCAS1 in hepatocellular carcinoma". Anticancer Res. 23 (6D): 4967–71. PMID 14981953.
Brill LM; Salomon AR; Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147654 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022339 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EBAG9 estrogen receptor binding site associated, antigen, 9".

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References

Further reading