TBC1D3

TBC1D3F
Identifiers
Aliases	TBC1D3F, TBC1D3, TBC1D3G, TBC1 domain family member 3F
External IDs	OMIM: 610809; HomoloGene: 74280; GeneCards: TBC1D3F; OMA:TBC1D3F - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,439,566 bp
RNA expression pattern
	Top expressed in
	testicle; ; right testis; ; left testis; ; right uterine tube; ; left uterine tube; ; bone marrow; ; duodenum; ; skeletal muscle tissue; ; gallbladder; ; blood;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity;
Cellular component	membrane; plasma membrane; intracellular anatomical structure; endomembrane system;
Biological process	intracellular protein transport; regulation of vesicle fusion; activation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	84218
	n/a
	ENSG00000275954
	n/a
	A6NER0
	n/a
	NM_032258
	n/a
	NP_115634
	n/a
	Wikidata
View/Edit Human

TBC1 domain family member 3E/3F is a protein that in humans is encoded by the TBC1D3F gene.^[3]^[4]

This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are two copies of this gene located within a cluster of chemokine genes on chromosome 17q; this record represents the more centromeric copy.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000275954 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hodzic D, Kong C, Wainszelbaum MJ, Charron AJ, Su X, Stahl PD (Nov 2006). "TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12". Genomics. 88 (6): 731–6. doi:10.1016/j.ygeno.2006.05.009. PMID 16863688.
^ ^a ^b "Entrez Gene: TBC1D3 TBC1 domain family, member 3".

Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes". Gene. 131 (2): 209–15. doi:10.1016/0378-1119(93)90295-E. PMID 8406013.
Onno M, Nakamura T, Mariage-Samson R, et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes". DNA Cell Biol. 12 (2): 107–18. doi:10.1089/dna.1993.12.107. PMID 8471161.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2507–11. doi:10.1073/pnas.0437015100. PMC 151371. PMID 12604796.
Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling". Mol. Cell. Biol. 23 (6): 2151–61. doi:10.1128/MCB.23.6.2151-2161.2003. PMC 149457. PMID 12612085.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000275954 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16863688-3] Hodzic D, Kong C, Wainszelbaum MJ, Charron AJ, Su X, Stahl PD (Nov 2006). "TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12". Genomics. 88 (6): 731–6. doi:10.1016/j.ygeno.2006.05.009. PMID 16863688.

[entrez-4] "Entrez Gene: TBC1D3 TBC1 domain family, member 3".

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[2]

[3]

[4]

References

Further reading