ADP-ribosylhydrolase 3

ADPRS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FOZ, 2FP0, 2G4K
Identifiers
Aliases	ADPRS, ARH3, ADP-ribosylhydrolase like 2, CONDSIAS, ADP-ribosylserine hydrolase, ADPRHL2
External IDs	OMIM: 610624; MGI: 2140364; HomoloGene: 9863; GeneCards: ADPRS; OMA:ADPRS - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	36,093,932 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	126,215,496 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; endothelial cell; ; gingival epithelium; ; middle temporal gyrus; ; bronchial epithelial cell; ; sperm; ; Brodmann area 23; ; nasal epithelium; ; pancreatic epithelial cell; ; pancreatic ductal cell;
	Top expressed in
	lip; ; right kidney; ; yolk sac; ; neural tube; ; embryo; ; embryo; ; proximal tubule; ; ventricular zone; ; epiblast; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; metal ion binding; poly(ADP-ribose) glycohydrolase activity;
Cellular component	cytoplasm; mitochondrion; nucleus; nucleoplasm; nuclear body; mitochondrial matrix;
Biological process	cellular response to superoxide;
	Sources:Amigo / QuickGO
Orthologs
	54936
	100206
	ENSG00000116863
	ENSMUSG00000042558
	Q9NX46
	Q8CG72
	NM_017825
	NM_133883
	NP_060295
	NP_598644
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(ADP-ribose) glycohydrolase ARH3 is an enzyme that in humans is encoded by the ADPRHL2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116863 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042558 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Glowacki G, Braren R, Firner K, Nissen M, Kühl M, Reche P, Bazan F, Cetkovic-Cvrlje M, Leiter E, Haag F, Koch-Nolte F (Jul 2002). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse". Protein Science. 11 (7): 1657–1670. doi:10.1110/ps.0200602. PMC 2373659. PMID 12070318.
^ Oka S, Kato J, Moss J (Jan 2006). "Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase". The Journal of Biological Chemistry. 281 (2): 705–713. doi:10.1074/jbc.M510290200. PMID 16278211.
^ "Entrez Gene: ADPRHL2 ADP-ribosylhydrolase like 2".

External links

Human ADPRHL2 genome location and ADPRHL2 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kernstock S, Koch-Nolte F, Mueller-Dieckmann J, Weiss MS, Mueller-Dieckmann C (Mar 2006). "Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase". Acta Crystallographica Section F. 62 (Pt 3): 224–227. doi:10.1107/S1744309106003435. PMC 2197168. PMID 16511307. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Mueller-Dieckmann C, Kernstock S, Lisurek M, von Kries JP, Haag F, Weiss MS, Koch-Nolte F (Oct 2006). "The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation". Proceedings of the National Academy of Sciences of the United States of America. 103 (41): 15026–15031. doi:10.1073/pnas.0606762103. PMC 1622773. PMID 17015823. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ono T, Kasamatsu A, Oka S, Moss J (Nov 2006). "The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases". Proceedings of the National Academy of Sciences of the United States of America. 103 (45): 16687–16691. doi:10.1073/pnas.0607911103. PMC 1636516. PMID 17075046.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116863 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042558 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12070318-5] Glowacki G, Braren R, Firner K, Nissen M, Kühl M, Reche P, Bazan F, Cetkovic-Cvrlje M, Leiter E, Haag F, Koch-Nolte F (Jul 2002). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse". Protein Science. 11 (7): 1657–1670. doi:10.1110/ps.0200602. PMC 2373659. PMID 12070318.

[pmid16278211-6] Oka S, Kato J, Moss J (Jan 2006). "Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase". The Journal of Biological Chemistry. 281 (2): 705–713. doi:10.1074/jbc.M510290200. PMID 16278211.

[entrez-7] "Entrez Gene: ADPRHL2 ADP-ribosylhydrolase like 2".

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References

External links

Further reading