HSD17B7

HSD17B7
Identifiers
Aliases	HSD17B7, PRAP, SDR37C1, hydroxysteroid (17-beta) dehydrogenase 7, hydroxysteroid 17-beta dehydrogenase 7
External IDs	OMIM: 606756; MGI: 1330808; HomoloGene: 40728; GeneCards: HSD17B7; OMA:HSD17B7 - orthologs
EC number	1.1.1.62
Gene location (Human)
Chr.	Chromosome 1 (human)
End	162,812,823 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	169,796,810 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; anterior pituitary; ; C1 segment; ; upper lobe of left lung; ; islet of Langerhans; ; ectocervix;
	Top expressed in
	vestibular sensory epithelium; ; skin of external ear; ; Paneth cell; ; ciliary body; ; facial motor nucleus; ; condyle; ; hair follicle; ; substantia nigra; ; iris; ; medullary collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; estradiol 17-beta-dehydrogenase activity; 3-keto sterol reductase activity;
Cellular component	integral component of membrane; plasma membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	estrogen biosynthetic process; cholesterol biosynthetic process; lipid metabolism; steroid biosynthetic process; nervous system development; cell differentiation; embryonic skeletal system development;
	Sources:Amigo / QuickGO
Orthologs
	51478
	15490
	ENSG00000132196
	ENSMUSG00000026675
	P56937
	O88736
	NM_001304512; NM_001304513; NM_016371
	NM_010476
	NP_001291441; NP_001291442; NP_057455
	NP_034606
	Wikidata
View/Edit Human	View/Edit Mouse

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.^[5]^[6]^[7]^[8]

The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132196 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026675 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Krazeisen A, Breitling R, Imai K, Fritz S, Moller G, Adamski J (Dec 1999). "Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1)". FEBS Lett. 460 (2): 373–9. doi:10.1016/S0014-5793(99)01366-6. PMID 10544267.
^ Peltoketo H, Nokelainen P, Piao YS, Vihko R, Vihko P (Aug 1999). "Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7". J Steroid Biochem Mol Biol. 69 (1–6): 431–9. doi:10.1016/S0960-0760(99)00064-3. PMID 10419022.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ ^a ^b "Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7".

Mendoza-Hernández G, Rendón JL, Díaz-Zagoya JC (1985). "A single step procedure for purification of estradiol 17 beta-dehydrogenase from human placenta". Biochem. Biophys. Res. Commun. 126 (1): 477–81. doi:10.1016/0006-291X(85)90630-8. PMID 3855619.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Törn S, Nokelainen P, Kurkela R, et al. (2003). "Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7". Biochem. Biophys. Res. Commun. 305 (1): 37–45. doi:10.1016/S0006-291X(03)00694-6. PMID 12732193.
Marijanovic Z, Laubner D, Moller G, et al. (2004). "Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis". Mol. Endocrinol. 17 (9): 1715–25. doi:10.1210/me.2002-0436. PMID 12829805.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ohnesorg T, Adamski J (2005). "Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7". J. Steroid Biochem. Mol. Biol. 94 (1–3): 259–61. doi:10.1016/j.jsbmb.2005.01.012. PMID 15862973.
Ohnesorg T, Adamski J (2006). "Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region". Mol. Cell. Endocrinol. 248 (1–2): 164–7. doi:10.1016/j.mce.2005.10.016. PMID 16356630.
Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J (2007). "Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis". J. Mol. Endocrinol. 37 (1): 185–97. doi:10.1677/jme.1.02043. PMID 16901934.
Smuc T, Pucelj MR, Sinkovec J, et al. (2007). "Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis". Gynecol. Endocrinol. 23 (2): 105–11. doi:10.1080/09513590601152219. PMID 17454161.
Guggenberger C, Ilgen D, Adamski J (2007). "Functional analysis of cholesterol biosynthesis by RNA interference". J. Steroid Biochem. Mol. Biol. 104 (3–5): 105–9. doi:10.1016/j.jsbmb.2007.03.001. PMID 17498944.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132196 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026675 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10544267-5] Krazeisen A, Breitling R, Imai K, Fritz S, Moller G, Adamski J (Dec 1999). "Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1)". FEBS Lett. 460 (2): 373–9. doi:10.1016/S0014-5793(99)01366-6. PMID 10544267.

[pmid10419022-6] Peltoketo H, Nokelainen P, Piao YS, Vihko R, Vihko P (Aug 1999). "Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7". J Steroid Biochem Mol Biol. 69 (1–6): 431–9. doi:10.1016/S0960-0760(99)00064-3. PMID 10419022.

[pmid19027726-7] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-8] "Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7".

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References

Further reading