LRRN2

LRRN2
Identifiers
Aliases	LRRN2, FIGLER7, GAC1, LRANK1, LRRN5, leucine rich repeat neuronal 2
External IDs	OMIM: 605492; MGI: 106037; HomoloGene: 21274; GeneCards: LRRN2; OMA:LRRN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 204,617,170 bp End 204,685,738 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 132,808,011 bp End 132,867,743 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Region I of hippocampus proper Brodmann area 10 Epithelium of choroid plexus ventricular zone nucleus accumbens anterior pituitary cingulate gyrus anterior cingulate cortex ganglionic eminence Top expressed in lateral geniculate nucleus medial dorsal nucleus dentate gyrus dentate gyrus of hippocampal formation granule cell subiculum medial geniculate nucleus primary visual cortex anterior amygdaloid area ventromedial nucleus dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity Cellular component integral component of membrane membrane extracellular space extracellular matrix Biological process cell adhesion axonogenesis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10446 16980 Ensembl ENSG00000170382 ENSMUSG00000026443 UniProt O75325 Q6PHP6 RefSeq (mRNA) NM_006338 NM_201630 NM_010732 RefSeq (protein) NP_006329 NP_963924 NP_034862 Location (UCSC) Chr 1: 204.62 – 204.69 Mb Chr 1: 132.81 – 132.87 Mb PubMed search
Wikidata
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Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Adams MD, Soares MB, Kerlavage AR, et al. (1993). "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library". Nat. Genet. 4 (4): 373–80. doi:10.1038/ng0893-373. PMID 8401585.