NRBP1

NRBP1
Identifiers
Aliases	NRBP1, BCON3, MADM, MUDPNP, NRBP, nuclear receptor binding protein 1
External IDs	OMIM: 606010; MGI: 2183436; HomoloGene: 8373; GeneCards: NRBP1; OMA:NRBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,442,259 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,408,910 bp
RNA expression pattern
	Top expressed in
	right testis; ; gastric mucosa; ; left testis; ; body of uterus; ; ectocervix; ; canal of the cervix; ; stromal cell of endometrium; ; granulocyte; ; muscle layer of sigmoid colon; ; right ovary;
	Top expressed in
	tail of embryo; ; genital tubercle; ; neural layer of retina; ; granulocyte; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; lip; ; muscle of thigh; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity; protein homodimerization activity;
Cellular component	cytoplasm; cell projection; cell cortex; membrane; endomembrane system; lamellipodium; nucleoplasm; cytosol;
Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport; transcription initiation from RNA polymerase II promoter; intracellular signal transduction; protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	29959
	192292
	ENSG00000115216
	ENSMUSG00000029148
	Q9UHY1
	Q99J45
NM_013392; NM_001321357; NM_001321358; NM_001321359; NM_001321361;
	NM_001321362; NM_001321363
	NM_147201; NM_001347326
NP_001308286; NP_001308287; NP_001308288; NP_001308290; NP_001308291;
	NP_001308292; NP_037524
	NP_001334255; NP_671734
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear receptor-binding protein is a protein that in humans is encoded by the NRBP1 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115216 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029148 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hooper JD, Baker E, Ogbourne SM, Sutherland GR, Antalis TM (Jul 2000). "Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein". Genomics. 66 (1): 113–8. doi:10.1006/geno.2000.6167. PMID 10843813.
^ De Langhe S, Haataja L, Senadheera D, Groffen J, Heisterkamp N (Apr 2002). "Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". Int J Mol Med. 9 (5): 451–9. doi:10.3892/ijmm.9.5.451. PMID 11956649.
^ "Entrez Gene: NRBP1 nuclear receptor binding protein 1".

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Lim R, Winteringham LN, Williams JH, et al. (2002). "MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1". J. Biol. Chem. 277 (43): 40997–1008. doi:10.1074/jbc.M206041200. PMID 12176995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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Chua JJ, Ng MM, Chow VT (2004). "The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure". Virus Res. 102 (2): 151–63. doi:10.1016/j.virusres.2004.01.025. PMID 15084397.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
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Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Wang H, Sun X, Luo Y, et al. (2006). "Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity". FEBS Lett. 580 (25): 6015–21. doi:10.1016/j.febslet.2006.10.002. PMID 17052710.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115216 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029148 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10843813-5] Hooper JD, Baker E, Ogbourne SM, Sutherland GR, Antalis TM (Jul 2000). "Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein". Genomics. 66 (1): 113–8. doi:10.1006/geno.2000.6167. PMID 10843813.

[pmid11956649-6] De Langhe S, Haataja L, Senadheera D, Groffen J, Heisterkamp N (Apr 2002). "Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". Int J Mol Med. 9 (5): 451–9. doi:10.3892/ijmm.9.5.451. PMID 11956649.

[entrez-7] "Entrez Gene: NRBP1 nuclear receptor binding protein 1".

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References

Further reading