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RNF34

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RNF34
Identifiers
AliasesRNF34, CARP-1, CARP1, RFI, RIF, RIFF, hRFI, ring finger protein 34
External IDsOMIM: 608299; MGI: 2153340; HomoloGene: 11839; GeneCards: RNF34; OMA:RNF34 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_194271
NM_001256858
NM_025126
NM_001394208

NM_030564

RefSeq (protein)

NP_001243787
NP_079402
NP_919247

NP_085041

Location (UCSC)Chr 12: 121.4 – 121.43 MbChr 5: 122.99 – 123.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.[5][6]

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170633Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029474Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sasaki S, Nakamura T, Arakawa H, Mori M, Watanabe T, Nagawa H, Croce CM (Jul 2002). "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer". Oncogene. 21 (32): 5024–30. doi:10.1038/sj.onc.1205627. PMID 12118383.
  6. ^ a b "Entrez Gene: RNF34 ring finger protein 34".

Further reading