DNASE1L1

DNASE1L1
Identifiers
Aliases	DNASE1L1, DNAS1L1, DNASEX, DNL1L, G4.8, XIB, deoxyribonuclease I-like 1, deoxyribonuclease 1 like 1
External IDs	OMIM: 300081; MGI: 109628; HomoloGene: 4896; GeneCards: DNASE1L1; OMA:DNASE1L1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,412,112 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,325,943 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; glutes; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; apex of heart; ; stromal cell of endometrium; ; triceps brachii muscle; ; tendon of biceps brachii;
	Top expressed in
	quadriceps femoris muscle; ; muscle of thigh; ; skeletal muscle tissue; ; bone marrow; ; zone of skin; ; esophagus; ; duodenum; ; granulocyte; ; lip; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nuclease activity; endonuclease activity; hydrolase activity; deoxyribonuclease activity; deoxyribonuclease I activity;
Cellular component	endoplasmic reticulum; extracellular region; specific granule lumen; nucleus;
Biological process	DNA metabolic process; DNA catabolic process; nucleic acid phosphodiester bond hydrolysis; neutrophil degranulation; DNA catabolic process, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	1774
	69537
	ENSG00000013563
	ENSMUSG00000019088
	P49184
	Q9D7J6
	NM_001009932; NM_001009933; NM_001009934; NM_001303620; NM_006730
	NM_001172154; NM_027109; NM_001370787
	NP_001009932; NP_001009933; NP_001009934; NP_001290549; NP_006721
	NP_001165625; NP_081385; NP_001357716
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxyribonuclease-1-like 1 is an enzyme that in humans is encoded by the DNASE1L1 gene.^[5]^[6]^[7]

This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. Alternate transcriptional splice variants, encoding the same protein, have been characterized.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013563 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019088 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Parrish JE, Ciccodicola A, Wehhert M, Cox GF, Chen E, Nelson DL (Feb 1996). "A muscle-specific DNase I-like gene in human Xq28". Hum Mol Genet. 4 (9): 1557–64. doi:10.1093/hmg/4.9.1557. PMID 8541839.
^ Pergolizzi R, Appierto V, Bosetti A, DeBellis GL, Rovida E, Biunno I (Jul 1996). "Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region". Gene. 168 (2): 267–70. doi:10.1016/0378-1119(95)00741-5. PMID 8654957.
^ ^a ^b "Entrez Gene: DNASE1L1 deoxyribonuclease I-like 1".

Chen EY; Zollo M; Mazzarella R; et al. (1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum. Mol. Genet. 5 (5): 659–68. doi:10.1093/hmg/5.5.659. PMID 8733135. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rodriguez AM; Rodin D; Nomura H; et al. (1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Malferrari G; Mazza U; Tresoldi C; et al. (1999). "Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders". Exp. Mol. Pathol. 66 (2): 123–30. doi:10.1006/exmp.1999.2254. PMID 10409440. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Brandenberger R; Wei H; Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Wiemann S; Arlt D; Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ross MT; Grafham DV; Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Shiokawa D; Shika Y; Saito K; et al. (2006). "Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X". Biochem. J. 392 (Pt 3): 511–7. doi:10.1042/BJ20051114. PMC 1316290. PMID 16107205. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Mehrle A; Rosenfelder H; Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Coy JF; Velhagen I; Himmele R; et al. (1996). "Isolation, differential splicing and protein expression of a DNase on the human X chromosome". Cell Death Differ. 3 (2): 199–206. PMID 17180083. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000013563 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019088 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8541839-5] Parrish JE, Ciccodicola A, Wehhert M, Cox GF, Chen E, Nelson DL (Feb 1996). "A muscle-specific DNase I-like gene in human Xq28". Hum Mol Genet. 4 (9): 1557–64. doi:10.1093/hmg/4.9.1557. PMID 8541839.

[pmid8654957-6] Pergolizzi R, Appierto V, Bosetti A, DeBellis GL, Rovida E, Biunno I (Jul 1996). "Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region". Gene. 168 (2): 267–70. doi:10.1016/0378-1119(95)00741-5. PMID 8654957.

[entrez-7] "Entrez Gene: DNASE1L1 deoxyribonuclease I-like 1".

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[5]

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[7]

References

Further reading