EID1

EID1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NUF
Identifiers
Aliases	EID1, C15orf3, CRI1, EID-1, IRO45620, PTD014, RBP21, PNAS-22, EP300 interacting inhibitor of differentiation 1
External IDs	OMIM: 605894; MGI: 1889651; HomoloGene: 49376; GeneCards: EID1; OMA:EID1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	48,880,173 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	125,516,705 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; Achilles tendon; ; germinal epithelium; ; right ventricle; ; internal globus pallidus; ; seminal vesicula; ; superficial temporal artery; ; ganglionic eminence; ; retinal pigment epithelium; ; myocardium;
	Top expressed in
	barrel cortex; ; dorsomedial hypothalamic nucleus; ; Gonadal ridge; ; median eminence; ; human fetus; ; fossa; ; atrium; ; habenula; ; condyle; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; histone acetyltransferase binding; transcription corepressor activity; histone acetyltransferase regulator activity;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytoplasmic ribonucleoprotein granule;
Biological process	cell cycle; cell differentiation; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of histone acetylation; regulation of cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	23741
	58521
	ENSG00000255302
	ENSMUSG00000091337
	Q9Y6B2
	Q9DCR4
	NM_014335
	NM_025613
	NP_055150
	NP_079889
	Wikidata
View/Edit Human	View/Edit Mouse

EP300-interacting inhibitor of differentiation 1 is a protein that in humans is encoded by the EID1 gene.^[5]^[6]^[7]

Interactions

EID1 has been shown to interact with EP300^[6]^[8] and Retinoblastoma protein.^[6]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000255302 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000091337 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M (June 2000). "Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1→q21.2". Cytogenet Cell Genet. 88 (3–4): 330–2. doi:10.1159/000015523. PMID 10828624.
^ ^a ^b ^c MacLellan WR, Xiao G, Abdellatif M, Schneider MD (December 2000). "A novel Rb- and p300-binding protein inhibits transactivation by MyoD". Mol Cell Biol. 20 (23): 8903–15. doi:10.1128/MCB.20.23.8903-8915.2000. PMC 86545. PMID 11073990.
^ "Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1".
^ ^a ^b Miyake, S; Sellers W R; Safran M; Li X; Zhao W; Grossman S R; Gan J; DeCaprio J A; Adams P D; Kaelin W G (December 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. ISSN 0270-7306. PMC 86544. PMID 11073989.

Ghosh AK, Varga J (2007). "The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis". J. Cell. Physiol. 213 (3): 663–71. doi:10.1002/jcp.21162. PMID 17559085.
Margottin F, Bour SP, Durand H, et al. (1998). "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif". Mol. Cell. 1 (4): 565–74. doi:10.1016/S1097-2765(00)80056-8. PMID 9660940.
Miyake S, Sellers WR, Safran M, et al. (2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. PMC 86544. PMID 11073989.
Wen H, Ao S (2001). "Identification and characterization of a novel human cDNA encoding a 21 kDa pRb-associated protein". Gene. 263 (1–2): 85–92. doi:10.1016/S0378-1119(00)00585-0. PMID 11223246.
Båvner A, Johansson L, Toresson G, et al. (2002). "A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP". EMBO Rep. 3 (5): 478–84. doi:10.1093/embo-reports/kvf087. PMC 1084100. PMID 11964378.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ledl A, Schmidt D, Müller S (2005). "Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor". Oncogene. 24 (23): 3810–8. doi:10.1038/sj.onc.1208539. PMID 15806172.
Krützfeldt M, Ellis M, Weekes DB, et al. (2005). "Selective ablation of retinoblastoma protein function by the RET finger protein". Mol. Cell. 18 (2): 213–24. doi:10.1016/j.molcel.2005.03.009. PMID 15837424.
Benevolenskaya EV, Murray HL, Branton P, et al. (2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Mol. Cell. 18 (6): 623–35. doi:10.1016/j.molcel.2005.05.012. PMID 15949438.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000255302 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000091337 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10828624-5] Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M (June 2000). "Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1→q21.2". Cytogenet Cell Genet. 88 (3–4): 330–2. doi:10.1159/000015523. PMID 10828624.

[pmid11073990-6] MacLellan WR, Xiao G, Abdellatif M, Schneider MD (December 2000). "A novel Rb- and p300-binding protein inhibits transactivation by MyoD". Mol Cell Biol. 20 (23): 8903–15. doi:10.1128/MCB.20.23.8903-8915.2000. PMC 86545. PMID 11073990.

[entrez-7] "Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1".

[pmid11073989-8] Miyake, S; Sellers W R; Safran M; Li X; Zhao W; Grossman S R; Gan J; DeCaprio J A; Adams P D; Kaelin W G (December 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. ISSN 0270-7306. PMC 86544. PMID 11073989.

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Interactions

References

Further reading