Sitagliptin/metformin
| Combination of | |
|---|---|
| Sitagliptin | Dipeptidyl peptidase-4 inhibitor |
| Metformin | Biguanide |
| Clinical data | |
| Trade names | Janumet, Januet, others |
| AHFS/Drugs.com | Professional Drug Facts |
| License data | |
| Pregnancy category |
|
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
| DrugBank | |
| UNII | |
| KEGG | |
Sitagliptin/metformin, sold under the brand name Janumet among others, is a combination medication used to treat type 2 diabetes.[2] It may be used in those whose blood sugar is not controlled with metformin and a sulfonylurea.[2][3] It is taken by mouth.[2]
Common side effects include diarrhea, headache, and upper respiratory tract infections.[1] Serious side effects may include lactic acidosis, pancreatitis, low blood sugar, heart failure, joint pain, and allergic reactions.[1] It has not been properly studied in people who are pregnant or breastfeeding.[4] It contains sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin (a biguanide).[1]
The combination was approved for medical use in the United States in 2007.[1] A month supply in the United Kingdom costs the NHS about 33.26 £ as of 2019.[2] In the United States the wholesale cost of this amount is about 433 USD.[5] In 2017, it was the 139th most commonly prescribed medication in the United States, with more than four million prescriptions.[6][7]
Society and culture
Brand names
As of 2018, the combination was marketed under several brand names, including Efficib, Janmet, Januet, Janumet, Jznumet, Ristaben Met, Ristfor, Siglimet, Sitamet, Sitar-M, Sliptin-M, Treviamet, and Velmetia.[8]
Price
A month supply in the United Kingdom costs the NHS about 33.26 £ as of 2019.[2] In the United States the wholesale cost of this amount is about 433 USD.[5] In Denmark 100 tablets (each 1,000 mg) cost over the counter in a pharmacy DKK 62.60 = US$ 9.40 = £7.50, thus a month supply in Denmark costs DKK 37.50 = US$ 5.70 = £ 4.50. The pharmacy buys wholesale at DKK 33.83 = US$ 5.11 = £4.10.[9]
References
- ^ a b c d e f "Janumet - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
- ^ a b c d e British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 682. ISBN 9780857113382.
- ^ Hayes J, Anderson R, Stephens JW (2016). "Sitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy". Drug Design, Development and Therapy. 10: 2263–70. doi:10.2147/DDDT.S93076. PMC 4958358. PMID 27486305.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ "Metformin / sitagliptin Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
- ^ a b "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
- ^ "Metformin Hydrochloride; Sitagliptin Phosphate - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
- ^ "International brands for Sitagliptin/metformin". Drugs.com. Retrieved 3 September 2018.
- ^ "Medicinpriser". Medicinpriser (in Danish). Retrieved 17 June 2019.
External links
- "Sitagliptin". Drug Information Portal. U.S. National Library of Medicine.
- "Metformin". Drug Information Portal. U.S. National Library of Medicine.
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