Tremorine

Tremorine
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine;
CAS Number	51-73-0;
PubChem CID	5534;
ChemSpider	5333;
UNII	U817VZ1URQ;
CompTox Dashboard (EPA)	DTXSID00199004 ;
Chemical and physical data
Formula	C12H20N2
Molar mass	192.300 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C2CCCN2CC#CCN1CCCC1;
	InChI InChI=1S/C12H20N2/c1-2-8-13(7-1)11-5-6-12-14-9-3-4-10-14/h1-4,7-12H2; Key:JSUAJTLKVREZHV-UHFFFAOYSA-N;

Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs.^[1]^[2]^[3]^[4]^[5] Beta blockers are also effective in counteracting the effects of tremorine.^[6]

References

^ Trautner EM, Gershon S (May 1959). "Use of tremorine for screening anti-parkinsonian drugs". Nature. 183 (4673): 1462–3. Bibcode:1959Natur.183.1462T. doi:10.1038/1831462a0. PMID 13657170.
^ Friedman AH, Aylesworth RJ, Friedman G (September 1963). "Tremorine: Its Effect on Amines of the Central Nervous System". Science. 141 (3586): 1188–90. Bibcode:1963Sci...141.1188F. doi:10.1126/science.141.3586.1188. PMID 14043364.
^ Menon M, Clark WG, Aures D (1971). "Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats". Pharmacological Research Communications. 3 (4): 345–350. doi:10.1016/0031-6989(71)90005-1.
^ Shinozaki H, Hirate K, Ishida M (May 1985). "Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency". Experimental Neurology. 88 (2): 303–15. doi:10.1016/0014-4886(85)90193-1. PMID 3987859.
^ Morais LC, Quintans-Júnior LJ, Franco CI, Almeida JR, Almeida RN (December 2004). "Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology". Pharmacology, Biochemistry, and Behavior. 79 (4): 745–9. doi:10.1016/j.pbb.2004.10.004. PMID 15582683.
^ Paul V (1986). "The role of adrenergic mechanism in tremorine-induced tremors in rats: antitremor effect of beta-adrenoceptor antagonists". Indian Journal of Physiology and Pharmacology. 30 (4): 307–12. PMID 2883120.

References

See also