SEPW1

SELENOW
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NPB
Identifiers
Aliases	SELENOW, selW, SEPW1, selenoprotein W, 1, selenoprotein W
External IDs	OMIM: 603235; MGI: 1100878; HomoloGene: 2263; GeneCards: SELENOW; OMA:SELENOW - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,784,686 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	15,656,327 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; prefrontal cortex; ; right frontal lobe; ; amygdala; ; hippocampus proper; ; cingulate gyrus; ; caudate nucleus; ; anterior cingulate cortex; ; nucleus accumbens; ; inferior ganglion of vagus nerve;
	Top expressed in
	saccule; ; supraoptic nucleus; ; triceps brachii muscle; ; temporal lobe; ; otic vesicle; ; globus pallidus; ; prefrontal cortex; ; dentate gyrus; ; aortic valve; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	antioxidant activity;
Cellular component	cytoplasm; cytosol;
Biological process	cellular oxidant detoxification; response to selenium ion;
	Sources:Amigo / QuickGO
Orthologs
	6415
	20364
	ENSG00000178980
	ENSMUSG00000041571
	P63302
	P63300
	NM_003009
	NM_009156
	NP_003000
	NP_033182
	Wikidata
View/Edit Human	View/Edit Mouse

Selenoprotein W is a protein that in humans is encoded by the SEPW1 gene.^[5]^[6]

Function

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178980 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041571 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gu QP, Beilstein MA, Vendeland SC, Lugade A, Ream W, Whanger PD (July 1997). "Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species". Gene. 193 (2): 187–96. doi:10.1016/S0378-1119(97)00113-3. PMID 9256076.
^ ^a ^b "Entrez Gene: SEPW1 selenoprotein W, 1".

External links

Overview of all the structural information available in the PDB for UniProt: P63300 (Mouse Selenoprotein W) at the PDBe-KB.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178980 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041571 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9256076-5] Gu QP, Beilstein MA, Vendeland SC, Lugade A, Ream W, Whanger PD (July 1997). "Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species". Gene. 193 (2): 187–96. doi:10.1016/S0378-1119(97)00113-3. PMID 9256076.

[entrez-6] "Entrez Gene: SEPW1 selenoprotein W, 1".

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Function

References

Further reading

External links