NDUFV3

NDUFV3
Identifiers
Aliases	NDUFV3, CI-10k, CI-9KD, NADH:ubiquinone oxidoreductase subunit V3
External IDs	OMIM: 602184; MGI: 1890894; HomoloGene: 10885; GeneCards: NDUFV3; OMA:NDUFV3 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,913,304 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,750,305 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; right ventricle; ; cardiac muscle tissue of right atrium; ; tibialis anterior muscle; ; vastus lateralis muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; body of tongue; ; parotid gland;
	Top expressed in
	right ventricle; ; tunica adventitia of aorta; ; digastric muscle; ; aortic valve; ; sternocleidomastoid muscle; ; ascending aorta; ; internal carotid artery; ; triceps brachii muscle; ; epithelium of stomach; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity; RNA binding; protein binding;
Cellular component	mitochondrial inner membrane; respirasome; membrane; mitochondrion; nucleoplasm; mitochondrial respiratory chain complex I;
Biological process	mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; mitochondrial ATP synthesis coupled electron transport;
	Sources:Amigo / QuickGO
Orthologs
	4731
	78330
	ENSG00000160194
	ENSMUSG00000024038
	P56181
	Q8BK30
	NM_001001503; NM_021075
	NM_001083891; NM_030087
	NP_001001503; NP_066553
	NP_001077360; NP_084363
	Wikidata
View/Edit Human	View/Edit Mouse

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial is an enzyme that in humans is encoded by the NDUFV3 gene.^[5]^[6]

The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160194 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024038 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ de Coo RF, Buddiger P, Smeets HJ, van Oost BA (Feb 1998). "Molecular cloning and characterization of the human mitochondrial NADH:oxidoreductase 10-kDa gene (NDUFV3)". Genomics. 45 (2): 434–7. doi:10.1006/geno.1997.4930. hdl:1765/57339. PMID 9344673.
^ ^a ^b "Entrez Gene: NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa".

Sled VD, Vinogradov AD (1993). "Kinetics of the mitochondrial NADH-ubiquinone oxidoreductase interaction with hexammineruthenium(III)". Biochim. Biophys. Acta. 1141 (2–3): 262–8. doi:10.1016/0005-2728(93)90051-G. PMID 8443212.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Berry A, Scott HS, Kudoh J, et al. (2001). "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region". Genomics. 68 (1): 22–9. doi:10.1006/geno.2000.6253. PMID 10950923.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zakharova NV, Zharova TV (2003). "Kinetic mechanism of mitochondrial NADH:ubiquinone oxidoreductase interaction with nucleotide substrates of the transhydrogenase reaction". Biochemistry Mosc. 67 (12): 1395–404. doi:10.1023/A:1021818312040. PMID 12600270.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kervinen M, Hinttala R, Helander HM, et al. (2006). "The MELAS mutations 3946 and 3949 perturb the critical structure in a conserved loop of the ND1 subunit of mitochondrial complex I". Hum. Mol. Genet. 15 (17): 2543–52. doi:10.1093/hmg/ddl176. PMID 16849371.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160194 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024038 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9344673-5] Coo RF, Buddiger P, Smeets HJ, van Oost BA (Feb 1998). "Molecular cloning and characterization of the human mitochondrial NADH:oxidoreductase 10-kDa gene (NDUFV3)". Genomics. 45 (2): 434–7. doi:10.1006/geno.1997.4930. hdl:1765/57339. PMID 9344673.

[entrez-6] "Entrez Gene: NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa".

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References

Further reading