Darusentan

Darusentan
Clinical data
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	Investigational;
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	12.5 hours
Identifiers
	IUPAC name (2S)-2-(4,6-Dimethoxypyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid;
CAS Number	171714-84-4 ;
PubChem CID	177236;
IUPHAR/BPS	3508;
ChemSpider	154336 ;
UNII	33JD57L6RW;
ChEMBL	ChEMBL23261 ;
CompTox Dashboard (EPA)	DTXSID1057664 ;
ECHA InfoCard	100.126.841
Chemical and physical data
Formula	C22H22N2O6
Molar mass	410.426 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC(=NC(=N1)O[C@H](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)OC;
	InChI InChI=1S/C22H22N2O6/c1-27-17-14-18(28-2)24-21(23-17)30-19(20(25)26)22(29-3,15-10-6-4-7-11-15)16-12-8-5-9-13-16/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1 ; Key:FEJVSJIALLTFRP-LJQANCHMSA-N ;
	(what is this?) (verify)

Darusentan (LU-135252; HMR-4005) is an endothelin receptor antagonist. Gilead Colorado, a subsidiary of Gilead Sciences,^[1] under license from Abbott Laboratories, is developing darusentan for the potential treatment of uncontrolled hypertension.

In June 2003, Myogen licensed the compound from Abbott for its application in the cancer field.^[2]

In May 2007, a randomized, double-blind, active control, parallel assignment, safety and efficacy phase III trial was initiated in subjects who had completed the maintenance period of the DAR-312 study.

References

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[1] Gilead Sciences

[2] Thomson Pharma

[1]

[2]

See also

References