Monica Riley
Monica Riley | |
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| Born | 1926 |
| Died | October 11, 2013 (aged 86–87) |
| Citizenship | American |
| Alma mater | Smith College, University of California Berkeley |
| Known for | Messenger RNA, Escherichia coli genome |
| Scientific career | |
| Institutions | University of California Davis, Stony Brook University, Marine Biological Laboratory in Woods Hole |
Monica Riley (1926 – October 11, 2013) was an American scientist who contributed to the discovery of messenger RNA in her Ph.D work with Arthur Pardee, and was later a pioneer in the exploration and computer representation of the Escherichia coli genome.
After graduating from Smith College with a chemistry degree in 1947, she studied Biochemistry at University of California Berkeley with Pardee.[1][2] Her Ph.D. work, together with the PaJaMo experiment, ruled out ribosomes as carriers of information to synthesize protein, leading to the discovery of messenger RNA.[3] After holding faculty positions at University of California Davis and Stony Brook University, she moved to the Marine Biological Laboratory in Woods Hole, staying there until age 80.[2]
As a senior scientist at MBL she was one of the four founding faculty members of the Josephine Bay Paul Center for Comparative Molecular Biology and Evolution led by Mitchell Sogin[4]. During this time, she co-founded the EcoCyc database of Escherichia coli metabolism,[5] leading the curation of metabolic pathways and genome information for Escherichia coli for over a decade, and developed classification systems for genes and proteins (including MultiFun), which were forerunners of Gene Ontology.[1][2]
References
- ^ a b Olena, Abby (November 7, 2013). "Genomics Pioneer Dies". The Scientist.
- ^ a b c Serres, Greta. "Monica Riley (1926 - 2013)". Marine Biological Laboratory in Woods Hole.
- ^ Crick, Francis (1988). What Mad Pursuit. pp. 118–119.
- ^ "Monica Riley (1926 – 2013)". The Bay Paul Center. 2013-10-29. Retrieved 2019-05-26.
- ^ Karp, Peter; Riley, Monica; Paley, Suzanne M.; Pelligrini-Toole, Alida. "EcoCyc: an encyclopedia of Escherichia coli genes and metabolism". Nucleic Acids Research. 24 (1): 32–39. doi:10.1093/nar/24.1.32. PMC 145574. PMID 8594595.
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