DOK3

DOK3
Identifiers
Aliases	DOK3, DOKL, docking protein 3
External IDs	OMIM: 611435; MGI: 1351490; HomoloGene: 8448; GeneCards: DOK3; OMA:DOK3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,511,274 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,677,109 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; spleen; ; right lung; ; lymph node; ; bone marrow; ; upper lobe of left lung; ; trabecular bone; ; appendix;
	Top expressed in
	granulocyte; ; blood; ; spleen; ; tibiofemoral joint; ; bone marrow; ; lymph node; ; mesenteric lymph nodes; ; fetal liver hematopoietic progenitor cell; ; stroma of bone marrow; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	membrane; cytoplasm; plasma membrane; secretory granule membrane; ficolin-1-rich granule membrane;
Biological process	neutrophil degranulation; Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	79930
	27261
	ENSG00000146094
	ENSMUSG00000035711
	Q7L591
	Q9QZK7
NM_001144875; NM_001144876; NM_001308235; NM_001308236; NM_024872;
	NM_001375794; NM_001375795; NM_001375796; NM_001375797; NM_001375798; NM_001375799; NM_001384137; NM_001384138; NM_001384139
	NM_013739
NP_001138347; NP_001138348; NP_001295164; NP_001295165; NP_079148;
	NP_001362723; NP_001362724; NP_001362725; NP_001362726; NP_001362727; NP_001362728; NP_001371066; NP_001371067; NP_001371068
	NP_038767
	Wikidata
View/Edit Human	View/Edit Mouse

Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146094 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035711 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lemay S, Davidson D, Latour S, Veillette A (Apr 2000). "Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling". Mol Cell Biol. 20 (8): 2743–54. doi:10.1128/MCB.20.8.2743-2754.2000. PMC 85490. PMID 10733577.
^ Favre C, Gerard A, Clauzier E, Pontarotti P, Olive D, Nunes JA (Feb 2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.
^ "Entrez Gene: DOK3 docking protein 3".

Cong F, Yuan B, Goff SP (2000). "Characterization of a Novel Member of the DOK Family That Binds and Modulates Abl Signaling". Mol. Cell. Biol. 19 (12): 8314–25. doi:10.1128/MCB.19.12.8314. PMC 84915. PMID 10567556.
Grimm J; Sachs M; Britsch S; et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Robson JD, Davidson D, Veillette A (2004). "Inhibition of the Jun N-Terminal Protein Kinase Pathway by SHIP-1, a Lipid Phosphatase That Interacts with the Adaptor Molecule Dok-3". Mol. Cell. Biol. 24 (6): 2332–43. doi:10.1128/MCB.24.6.2332-2343.2004. PMC 355862. PMID 14993273.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Honma M; Higuchi O; Shirakata M; et al. (2007). "Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases". Genes Cells. 11 (2): 143–51. doi:10.1111/j.1365-2443.2006.00926.x. PMID 16436051. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146094 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035711 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10733577-5] Lemay S, Davidson D, Latour S, Veillette A (Apr 2000). "Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling". Mol Cell Biol. 20 (8): 2743–54. doi:10.1128/MCB.20.8.2743-2754.2000. PMC 85490. PMID 10733577.

[pmid12595900-6] Favre C, Gerard A, Clauzier E, Pontarotti P, Olive D, Nunes JA (Feb 2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.

[entrez-7] "Entrez Gene: DOK3 docking protein 3".

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[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading