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Jonathan Marchini

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Jonathan Marchini
Born
Jonathan Laurence Marchini

(1973-05-19) 19 May 1973 (age 51)
Chichester
NationalityUK
Alma mater
Awards
Scientific career
Institutions
Thesis The Statistical Analysis of Brain Images  (2002)
Doctoral advisorBrian Ripley.[2]
Websitejmarchini.org

Jonathan Laurence Marchini (born 19 May 1973)[3] is a Bayesian statistician and professor of statistical genomics[4] in the Department of Statistics at the University of Oxford, a tutorial fellow in statistics at Somerville College,[5] Oxford and a co-founder and director of GENSCI LTD.[6] He co-leads the Haplotype Reference Consortium.[7]

Education

He obtained a Bachelor of Science degreed in Pure Mathematics and Mathematical Statistics from Exeter University from 1991-94.[8] He then obtained a PGCE in Mathematics Education from the West Sussex Institute of Higher Education from 1994-5. He completed his DPhil in the Department of Statistics at the University of Oxford supervised by Professor Brian Ripley from 1998-2002.[9]

Career and Research

Marchini spent three years working as a VSO volunteer teaching A-level Mathematics at Tosamaganga Secondary school, near Iringa, Tanzania, between September 1995 and September 1998.[10]

From 2002 to 2005 he held a Wellcome Trust Training Fellowship in Mathematical Biology, under the supervision of Prof Lon Cardon and Prof Peter Donnelly.

In 2006 he was appointed as a university lecturer (associate professor) in statistical genomics in the Department of Statistics at the University of Oxford and a senior research fellow at Mansfield College. In 2007 he became an affiliated group leader at the Wellcome Trust Center of Human Genetics[11] at the University of Oxford. In 2010 he was re-appointed until retirement [12]

In 2015 he was promoted to professor of statistical genomics[13][14]

Marchini's research focusses on statistical genetics and population genetics, with a particular emphasis on methods development for genome-wide association studies. He has worked on haplotype estimation,[15][16][17][18] genotype imputation,[19] genotype calling from arrays and sequencing, sparse tensor decomposition for RNA-seq datasets,[20] population structure,[21] phenotype prediction and mixed models,[22] gene-gene interactions[23] and brain imaging genetics.[24]

He was a member of the analysis team for the International HapMap Project, the Wellcome Trust Case-Control Consortium, the 1000 Genomes Project and the UK10K Project. His research group was responsible for the haplotype estimation and genotype imputation for the UK Biobank dataset. He co-leads the Haplotype Reference Consortium.[25]

He has been an ISI Highly Cited Researcher from 2014-2018[26]

He has acted as an expert witness in a patent trial[27]

Awards

In 2012 he was awarded a Philip Leverhulme Prize[28] for "leading the way by constructing powerful and ingenious novel statistical methodology for population and medical genetics, together with associated fast computational algorithms and software."

References

  1. ^ "Leverhulme website" (PDF). Archived from the original (PDF) on 2018-04-02. Retrieved 2018-04-01.
  2. ^ Marchini, J.; Ripley, B. (2000). "A New Statistical Approach to Detecting Significant Activation in Functional MRI. Molecular evolution". NeuroImage. 12 (4): 366–80. doi:10.1006/nimg.2000.0628. PMID 10988031.
  3. ^ "Companies house record".
  4. ^ "Marchini website".
  5. ^ "Somerville website".
  6. ^ "Companies house record".
  7. ^ "HRC website".
  8. ^ "Somerville College Report" (PDF).
  9. ^ Marchini, Jonathan L.; Ripley, Brian D. (October 2000). "A New Statistical Approach to Detecting Significant Activation in Functional MRI". NeuroImage. 12 (4): 366–380. doi:10.1006/nimg.2000.0628. PMID 10988031.
  10. ^ "Photo album".
  11. ^ "WTCHG website".
  12. ^ "Oxford Gazette link".
  13. ^ "Oxford Gazette link".
  14. ^ "Oxford Gazette link".
  15. ^ O'Connell, Jared; Sharp, Kevin; Shrine, Nick; Wain, Louise; Hall, Ian; Tobin, Martin; Zagury, Jean-Francois; Delaneau, Olivier; Marchini, Jonathan (6 June 2016). "Haplotype estimation for biobank-scale data sets". Nature Genetics. 48 (7): 817–820. doi:10.1038/ng.3583. PMC 4926957. PMID 27270105.
  16. ^ O'Connell, Jared; Gurdasani, Deepti; Delaneau, Olivier; Pirastu, Nicola; Ulivi, Sheila; Cocca, Massimiliano; Traglia, Michela; Huang, Jie; Huffman, Jennifer E.; Rudan, Igor; McQuillan, Ruth; Fraser, Ross M.; Campbell, Harry; Polasek, Ozren; Asiki, Gershim; Ekoru, Kenneth; Hayward, Caroline; Wright, Alan F.; Vitart, Veronique; Navarro, Pau; Zagury, Jean-Francois; Wilson, James F.; Toniolo, Daniela; Gasparini, Paolo; Soranzo, Nicole; Sandhu, Manjinder S.; Marchini, Jonathan; Gibson, Greg (17 April 2014). "A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness". PLoS Genetics. 10 (4): e1004234. doi:10.1371/journal.pgen.1004234. PMC 3990520. PMID 24743097.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  17. ^ Delaneau, Olivier; Howie, Bryan; Cox, Anthony J.; Zagury, Jean-François; Marchini, Jonathan (October 2013). "Haplotype Estimation Using Sequencing Reads". The American Journal of Human Genetics. 93 (4): 687–696. doi:10.1016/j.ajhg.2013.09.002. PMC 3791270. PMID 24094745.
  18. ^ Delaneau, Olivier; Zagury, Jean-Francois; Marchini, Jonathan (1 January 2013). "Improved whole-chromosome phasing for disease and population genetic studies". Nature Methods. 10 (1): 5–6. doi:10.1038/nmeth.2307. PMID 23269371.
  19. ^ Howie, Bryan N.; Donnelly, Peter; Marchini, Jonathan; Schork, Nicholas J. (19 June 2009). "A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies". PLoS Genetics. 5 (6): e1000529. doi:10.1371/journal.pgen.1000529. PMC 2689936. PMID 19543373.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  20. ^ Hore, Victoria; Viñuela, Ana; Buil, Alfonso; Knight, Julian; McCarthy, Mark I; Small, Kerrin; Marchini, Jonathan (1 August 2016). "Tensor decomposition for multiple-tissue gene expression experiments". Nature Genetics. 48 (9): 1094–1100. doi:10.1038/ng.3624. PMC 5010142. PMID 27479908.
  21. ^ Marchini, Jonathan; Cardon, Lon R; Phillips, Michael S; Donnelly, Peter (28 March 2004). "The effects of human population structure on large genetic association studies". Nature Genetics. 36 (5): 512–517. doi:10.1038/ng1337. PMID 15052271.
  22. ^ Dahl, Andrew; Iotchkova, Valentina; Baud, Amelie; Johansson, Åsa; Gyllensten, Ulf; Soranzo, Nicole; Mott, Richard; Kranis, Andreas; Marchini, Jonathan (22 February 2016). "A multiple-phenotype imputation method for genetic studies". Nature Genetics. 48 (4): 466–472. doi:10.1038/ng.3513. PMC 4817234. PMID 26901065.
  23. ^ Marchini, Jonathan; Donnelly, Peter; Cardon, Lon R (27 March 2005). "Genome-wide strategies for detecting multiple loci that influence complex diseases". Nature Genetics. 37 (4): 413–417. doi:10.1038/ng1537. PMID 15793588.
  24. ^ Elliott, Lloyd T.; Sharp, Kevin; Alfaro-Almagro, Fidel; Shi, Sinan; Miller, Karla; Douaud, Gwenaëlle; Marchini, Jonathan; Smith, Stephen (2018). "BioRxiv paper". doi:10.1101/178806. {{cite journal}}: Cite journal requires |journal= (help)
  25. ^ "HRC website".
  26. ^ "ISI Highly Cited Researchers".
  27. ^ "Illumina vs Premaitha".
  28. ^ "Leverhulme website" (PDF). Archived from the original (PDF) on 2018-04-02. Retrieved 2018-04-01.
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