UQ Holder! is a Japanese manga series written and illustrated by Ken Akamatsu. It began its serialization in the manga magazine Weekly Shōnen Magazine on August 28, 2013. Its individual chapters have been collected into twenty-three tankōbon volumes by Kodansha, the first released on December 17, 2013. The story is set in the same universe as Akamatsu's previous work Negima! Magister Negi Magi, but over 70 years later, it follows the adventures of a young boy named Tōta Konoe who is transformed into a vampire by his foster parent Yukihime and joins a secret society composed of immortal beings called UQ Holder.
The series is licensed for English language release in North America by Kodansha USA under the Kodansha Comics imprint, who published the first volume on March 18, 2014. As the series is published in Japan, it is also released simultaneously in English digitally by Crunchyroll. Individual chapters of the series are called stages.
Village boy Tōta Konoe and his friends have been training to someday beat their school teacher Yukihime in physical combat so they can go to the big city. Using a bracelet to restrict Yukihime's power, Tachibana, a teacher who is actually a bounty hunter, attacks Yukihime, and mortally wounds Tōta. Yukihime, who is actually Evangeline A.K. McDowell, a 700-year-old vampire mage, has Tōta drink her blood to realize his powers as an immortal vampire which she bestowed to him two years prior. Tōta defeats Tachibana, and the two leave the village to journey to the city. Along the way, they meet some village kids including Shinobu Yuki who aspires to be a spaceship racer. Tota meets Kurōmaru Tokisaka, a feminine-looking boy who is actually an assassin sent to slay Yukihime. Kurōmaru and Tōta agree to fight, but Kurōmaru loses, and Tōta's condition is that Kurōmaru be his best friend. At a hot springs spa town, Tōta and Kurōmaru challenge Yukihime to steal her bath towel. Kurōmaru agrees to be Yukihime's disciple, and Tōta talks about wanting to form a team of immortals to help the world. As her assistants arrive to retrieve her and the boys, Yukihime reveals she has already formed a group of immortal beings called UQ Holder.
8. "The Strength of a Leader" (リーダーの力, "Rīdā no Chikara")
9. "Let the Training Begin" (修行開始, "Shugyō Kaishi")
10. "The Gravity Blade" (重力剣, "Jūryoku Ken")
11. "Beast Exterminators" (魔獣退治, "Majū Taiji")
12. "The First Mission" (初任務, "Hatsu Ninmu")
13. "I Refuse To Be Beaten" (負けられない, "Makerarenai")
14. "Magic Apps" (魔法アプリ, "Mahō Apuri")
15. "The Fruits of Training" (修行の成果, "Shugyō no Seika")
16. "The Blind Immortal Hunter" (盲目の不死狩り, "Mōmoku no Fushigari")
17. "The Assassins Strike" (刺客襲来, "Shikaku Shūrai")
At UQ Holder headquarters, Yukihime's attendants immediately celebrate her return. When Tōta declares he is joining UQ Holder, he and Kurōmaru are given a trial of having to escape from the underground area with a time limit of eight years. They meet UQ Holder leader Jinbei Shishido, who trains the two and has Tōta master the gravity blade. After a month, Tōta and Kurōmaru defeat the monsters. They work with UQ Holder member Karin Yuuki to defend a village from some land sharks and an attacker named Wrecking Ball. After being defeated by Kurōmaru and Karin in arm wrestling, Tōta trains in the movement art of shundō where he learns some techniques from a passing martial artist named Kaito. Karin learns of Kurōmaru's characteristic of being genderless, and tells Kurōmaru to choose being a female. Chao Xinxai, a special forces member of the immortal hunting group PMSCS, attacks Karin.
25. "Take Hold of The World" (世界を掴む, "Sekai o Tsukamu")
26. "Karin in Crisis" (夏凛の危機, "Karin no Kiki")
27. "Tōta vs. Nagumo" (刀太VS南雲, "Tōta VS Nagumo")
28. "Enter the Numbers!" (ナンバーズ、来る!, "Nanbāzu, Kitaru!")
PMSCS's Powerful Hand group attacks the UQ Holder members at the city slums while burning down the city. A werewolf binds Tōta with a sealing spell, leaving Kurōmaru to fight him. Meanwhile, Karin fights and defeats the shadow puppet master mage Chao Xinxai. The werewolf is winning when one of the kids Ruki tries to protect Kurōmaru and Tōta is able to break the binding spell with the powerful transformation Magia Erebea. Tōta defeats the werewolf, who is revealed to be Kaito, but spares his life. Nagumo attacks Karin, sending her to the Moon. Nagumo has the PMSCS capture Tōta, but Yukihime and the other UQ Holder members arrive.
38. "The Operation Is a Go!!" (作戦決行!!, "Sakusen Kekkō!!")
39. "The Battle Continues!!" (戦闘続行!!, "Sentō Zokkō!!")
40. "Carrying Out the Plan" (あの時, "Ano Toki")
Jinbei defeats Nagumo, and Yukihime uses her ice spell to put out the fires. Tōta accompanies Kirië Sakurame, a UQ Holder member and primary patron of the group who has the ability to rewind time, using it to survive multiple assassination attempts, later revealed to be coming from Chao Xinxai. Their mission is to meet with Fate Averruncus, UQ Holder's enemy and former friend/rival of Negi Springfield, and to stop him from claiming Tōta's head and from destroying UQ Holder. The mission is almost a failure as Fate almost takes Tōta's friends hostage and petrifies Kirië. Tōta and the others are forced to fight Fate and his assistants. But Kirië's petrification expires and she is able to pull Fate and the others back in time with her.
44. "The Rules of the Academy City" (学園都市のルール, "Gakuen Toshi no Rūru")
45. "Serial Killer" (連続殺人, "Renzoku Satsujin")
46. "The Psion" (超能力者, "Chōnōryoku-sha")
47. "Psion VS Immortals" (超能力者VS.不死者, "Chōnōryoku-sha VS. Fushisha")
48. "Pleasant Memories" (楽しい記憶, "Tanoshii Kioku")
49. "The Truth of the Matter" (事件の真相, "Jiken no Shinsō")
50. "The Real Killer" (真犯人, "Shinhannin")
51. "Sayoko and Santa" (小夜子と三太, "Sayoko to Santa")
After Fate and Evangeline fight, Fate offers to answer questions posed by the UQ Holder members, during which Tota learns that Fate wants to use him in order to find Negi Springfriend and to save the world, but that Fate also killed Tota's parents. Although Tota doesn't agree to follow Fate, he agrees to train up before meeting him again. Tota, Kuromaru, Karin, and Ikku work undercover as students of the city academy in order to track down an immortal who has been murdering students. They room with shut-in student Santa Sasaki, who unbeknownst to the gang, had been tracking the UQ Holder members and seems to be the immortal they are looking for. Kuromaru learns that Santa has been dead for eight years and he is a vengeful spirit called a revenant. But more murders occur, and Karin is attacked by Sayoko, who was the actual murderer, and the necromancer that turned Santa into the revenant.
52. "Town under Attack" (襲われた街, "Osowareta Machi")
53. "Hope Arrives" (希望はやって来る, "Kibō wa Yattekuru")
54. "Zombified" (ゾンビ化, "Zonbi-ka")
55. "Goodbye" (さようなら, "Sayōnara")
56. "Sayoko and Santa" (小夜子と三太, "Sayoko to Santa")
57. "The Battle Heats Up" (戦闘激化, "Sentō Gekika")
58. "Airborne Battle of Abilities" (能力×空中戦, "Nōryoku × Kūchū-sen")
59. "A Sworn Friend" (盟友として, "Meiyū to Shite")
60. "It Ends" (全て終わり, "Subete Owari")
61. "Kuromaru's Woes" (九郎丸の苦悩, "Kurōmaru no Kunō")
62. "Livening Things Up" (一層賑やかに, "Issō Nigiyaka ni")
Sayoko uses a virus that turns the students and city folk into a horde of zombies. She disables Kirie, preventing her from going back to the save point, and then defeats Tota and the others. Breaking free of Sayoko's influence, Santa tries to help the populace. He thinks about his past with Sayoko, and how he was murdered, but that he no longer wants revenge. While Tota and Karin recover from the virus, Tota has to deal with Kuromaru. Santa is able to reach Sayoko and convince her to stop the killing, after which Sayoko dissipates into sakura flower petals. Kirie takes the gang back to the save point; Santa brings two of the petals, at which Sayoko then acknowledges she has been defeated and that it is time for her to leave the world. Santa joins UQ Holder. The gang pay a visit to the baths, during which Kuromaru struggles with his feelings for Tota now that he has another comrade in Santa.
66. "Define the Relationship" (関係の名前, "Kankei no Namae")
67. "What if I Ran Away from Home?" (家出してみたら, "Iede Shite Mitara")
68. "The Preliminaries" (予選会, "Yosenkai")
69. "Using Apps" (アプリ使用, "Apuri Shiyō")
70. "Attacker" (襲撃者, "Shūgekisha")
71. "The Truth About Touta" (刀太の真実, "Tōta no Shinjitsu")
72. "Caring Friends" (仲間思い, "Nakama Omoi")
73. "Recognition" (認識, "Ninshiki")
74. "Avoiding a Nightmare" (悪夢の回避, "Akumu no Kaihi")
Tota meets Mana Tatsumiya, a former student of Negi and the acting director for Amanomihashira Academy, who informs him of an upcoming magic/fighting tournament that will give him a chance to go to the orbital station. When Yukihime learns that Negi Springfield is entering the tournament, and that the message was authenticated by Fate, she cancels Tota's registration and forbids him from entering, as she will personally see to the matter. Tota leaves the headquarters and meets a prospective fighter who explains how one can enter the tournament by accumulating points in a qualification round. When Tota is attacked by a girl in a cloak who is able to defeat him, his comrades at UQ Holder save him. The girl tells him that he is not the grandson of Negi Springfield, but a cheap clone. But the girl threatens to destroy the city unless Tota makes it into the tournament.
These chapters have yet to be published in a tankōbon volume. They were originally serialized in Japanese in issues of Weekly Shōnen Magazine and in English in issues of Crunchyroll Manga from February 2019.