PIP5K1A

PIP5K1A
Identifiers
Aliases	PIP5K1A, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
External IDs	OMIM: 603275; MGI: 107929; HomoloGene: 93492; GeneCards: PIP5K1A; OMA:PIP5K1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 151,197,949 bp End 151,249,536 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.1 Start 95,058,530 bp End 95,106,930 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis epithelium of colon left testis sural nerve Achilles tendon gastric mucosa skin of leg left uterine tube skin of abdomen islet of Langerhans Top expressed in gastrula Rostral migratory stream decidua olfactory tubercle cumulus cell CA3 field dentate gyrus pineal gland dentate gyrus of hippocampal formation granule cell primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding 1-phosphatidylinositol-4-phosphate 5-kinase activity kinase activity kinase binding protein binding phosphatidylinositol phosphate kinase activity ATP binding 1-phosphatidylinositol-3-phosphate 5-kinase activity 1-phosphatidylinositol-5-kinase activity phosphatidylinositol-3,4-bisphosphate 5-kinase activity 1-phosphatidylinositol-3-phosphate 4-kinase activity Cellular component nuclear speck mRNA cleavage and polyadenylation specificity factor complex cell projection membrane focal adhesion ruffle plasma membrane nucleoplasm ruffle membrane nucleus lamellipodium cytoplasm cytosol Biological process fibroblast migration actin cytoskeleton reorganization phosphatidylinositol metabolic process activation of GTPase activity phosphorylation keratinocyte differentiation focal adhesion assembly phospholipid biosynthetic process phagocytosis cell chemotaxis glycerophospholipid metabolic process ruffle assembly cell migration signal transduction phosphatidylinositol phosphate biosynthetic process regulation of phosphatidylinositol 3-kinase signaling phosphatidylinositol biosynthetic process protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8394 18720 Ensembl ENSG00000143398 ENSMUSG00000028126 UniProt Q99755 P70182 RefSeq (mRNA) NM_001135636 NM_001135637 NM_001135638 NM_003557 NM_001330689 NM_001293707 NM_008847 RefSeq (protein) NP_001129108 NP_001129109 NP_001129110 NP_001317618 NP_003548 NP_001280636 NP_032873 Location (UCSC) Chr 1: 151.2 – 151.25 Mb Chr 3: 95.06 – 95.11 Mb PubMed search
Wikidata
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Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.

Further reading

• Honda A, Nogami M, Yokozeki T, et al. (1999). "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation". Cell. 99 (5): 521–32. doi:10.1016/S0092-8674(00)81540-8. PMID 10589680.
• Jones DH, Morris JB, Morgan CP, et al. (2000). "Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment". J. Biol. Chem. 275 (18): 13962–6. doi:10.1074/jbc.C901019199. PMID 10747863.
• Divecha N, Roefs M, Halstead JR, et al. (2000). "Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity". EMBO J. 19 (20): 5440–9. doi:10.1093/emboj/19.20.5440. PMC 314009. PMID 11032811.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Doughman RL, Firestone AJ, Wojtasiak ML, et al. (2003). "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling". J. Biol. Chem. 278 (25): 23036–45. doi:10.1074/jbc.M211397200. PMID 12682053.
• Chang JD, Field SJ, Rameh LE, et al. (2004). "Identification and characterization of a phosphoinositide phosphate kinase homolog". J. Biol. Chem. 279 (12): 11672–9. doi:10.1074/jbc.M309721200. PMID 14701839.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kisseleva M, Feng Y, Ward M, et al. (2005). "The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha". Mol. Cell. Biol. 25 (10): 3956–66. doi:10.1128/MCB.25.10.3956-3966.2005. PMC 1087706. PMID 15870270.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Halstead JR, van Rheenen J, Snel MH, et al. (2006). "A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis". Curr. Biol. 16 (18): 1850–6. doi:10.1016/j.cub.2006.07.066. PMID 16979564.
• Im YJ, Perera IY, Brglez I, et al. (2007). "Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum". Plant Cell. 19 (5): 1603–16. doi:10.1105/tpc.107.051367. PMC 1913725. PMID 17496116.