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Sebastian Amigorena

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Sebastian Amigorena
Born1960
Buenos Aires, Argentina
Academic background
ThesisFcR expression in B lymphocytes (1990)
Doctoral advisorWolf H. Fridman
Other advisorsIra Mellman
Academic work
DisciplineImmunologist
InstitutionsInstitut Curie
Notable studentsAna Rodriguez (postdoc '97–'99)[1]

Sebastian Amigorena is an Argentinian-French immunologist and a Team Leader at the Institut Curie.[2]

Education and career

Sebastian Amigorena was born in 1960 in Buenos Aires.[3] He studied biochemistry at Paris Diderot University, earning his Ph.D. in 1990 under the supervision of Wolf H. Fridman, with a thesis titled "FcR expression in B lymphocytes".[4] He then went on to a postdoctoral fellowship in the laboratory of Ira Mellman at Yale Medical School.[3] In 1995, he joined the faculty of the Institut Curie as a team leader, and is now director of the laboratory of Immunity and Cancer.[3] He was elected to the French Academy of Sciences in 2005.[3][5]

Research

Amigorena's research focuses on antigen presentation by dendritic cells.[3] In particular, Amigorena's research group has studied the processes by which dendritic cells take up, process, and display antigens to T cells, as well as how this process is regulated by regulatory T cells.[3][6]

Notable works

  • Guermonprez P, Saveanu L... Amigorena S (2003). ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature. 425(6956): pgs. 397-402
  • Thery C, Boussac M... Amigorena S (2001). Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. Journal of Immunology. 166(12): pgs. 7309-7318
  • Regnault A, Lankar D... Amigorena S (1999). Fcy receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immuno complex internalization. Journal of Experimental Medicine. 189(2): pgs. 371-380
  • Thery C, Regnault A... Amigorena S (1999). Molecular characterization of dendritic cell-derived exosomes: selective accumulation of the heat shock protein hsc73. Journal of Cell Biology. 147(3): pgs. 599-610
  • Zitvogel L, Regnault A... Amigorena S (1998). Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nature Medicine. 4(5): pgs. 594-600

References

  1. ^ "Rodriguez Lab". New York University. Retrieved 17 July 2019.
  2. ^ "Sebastian Amigorena". Institut Curie. Retrieved 17 July 2019.
  3. ^ a b c d e f "Short CV: Sebastian Amigorena" (PDF). 15th International Symposium on Dendritic Cells. Retrieved 17 July 2019.
  4. ^ "Sebastian Amigorena" (PDF). French Academy of Sciences. Retrieved 17 July 2019.
  5. ^ "Sebastian Amigorena". French Academy of Sciences. Retrieved 17 July 2019.
  6. ^ "Symposium Speaker: Sebastian Amigorena". International Congress of Immunology. Retrieved 17 July 2019.
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