NAB1

NAB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YUF
Identifiers
Aliases	NAB1, NGFI-A binding protein 1
External IDs	OMIM: 600800; MGI: 107564; HomoloGene: 4352; GeneCards: NAB1; OMA:NAB1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	190,692,766 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	52,539,838 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; skin of hip; ; skin of thigh; ; Achilles tendon; ; endothelial cell; ; Epithelium of choroid plexus; ; ventricular zone; ; epithelium of colon; ; optic nerve; ; tendon of biceps brachii;
	Top expressed in
	carotid body; ; saccule; ; molar; ; otic placode; ; conjunctival fornix; ; calvaria; ; ascending aorta; ; skin of external ear; ; iris; ; seminal vesicula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; transcription coregulator activity;
Cellular component	nucleus;
Biological process	Schwann cell differentiation; myelination; endochondral ossification; regulation of epidermis development; transcription, DNA-templated; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	4664
	17936
	ENSG00000138386
	ENSMUSG00000002881
	Q13506
	Q61122
	NM_005966; NM_001321312; NM_001321313; NM_001321314; NM_001321315
	NM_008667
	NP_001308241; NP_001308242; NP_001308243; NP_001308244; NP_005957
	NP_032693
	Wikidata
View/Edit Human	View/Edit Mouse

NGFI-A-binding protein 1 is a protein that in humans is encoded by the NAB1 gene.^[5]^[6]^[7]^[8]

Interactions

NAB1 has been shown to interact with Zif268.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138386 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002881 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Russo MW, Sevetson BR, Milbrandt J (Aug 1995). "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription". Proc Natl Acad Sci U S A. 92 (15): 6873–7. Bibcode:1995PNAS...92.6873R. doi:10.1073/pnas.92.15.6873. PMC 41432. PMID 7624335.
^ Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. doi:10.1128/MCB.16.7.3545. PMC 231349. PMID 8668170.
^ Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J (Jan 1998). "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain". Mol Cell Biol. 18 (1): 512–24. doi:10.1128/MCB.18.1.512. PMC 115883. PMID 9418898.
^ "Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Thiel G, Kaufmann K, Magin A, et al. (2000). "The human transcriptional repressor protein NAB1: expression and biological activity". Biochim. Biophys. Acta. 1493 (3): 289–301. doi:10.1016/s0167-4781(00)00207-4. PMID 11018254.
Qiu FH, Devchand PR, Wada K, Serhan CN (2002). "Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils". FASEB J. 15 (14): 2736–8. doi:10.1096/fj.01-0576fje. PMID 11687510. S2CID 23166941.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics. 4 (1): 37–41. doi:10.1007/s10048-001-0124-2. PMID 12030330. S2CID 1928229.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138386 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002881 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7624335-5] Russo MW, Sevetson BR, Milbrandt J (Aug 1995). "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription". Proc Natl Acad Sci U S A. 92 (15): 6873–7. Bibcode:1995PNAS...92.6873R. doi:10.1073/pnas.92.15.6873. PMC 41432. PMID 7624335.

[pmid8668170-6] Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. doi:10.1128/MCB.16.7.3545. PMC 231349. PMID 8668170.

[pmid9418898-7] Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J (Jan 1998). "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain". Mol Cell Biol. 18 (1): 512–24. doi:10.1128/MCB.18.1.512. PMC 115883. PMID 9418898.

[entrez-8] "Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)".

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[3]

[4]

[5]

[6]

[7]

[8]

Interactions

References

Further reading