Ribosomal protein L19 leader
Appearance
L19_leader | |
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![]() Consensus secondary structure and sequence conservation of Ribosomal protein L19 leader | |
Identifiers | |
Symbol | L19_leader |
Rfam | RF00556 |
Other data | |
RNA type | Cis-reg; leader |
GO | GO:0010468 |
SO | SO:0000233 |
PDB structures | PDBe |
L19-Flavobacteria | |
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![]() Consensus secondary structure and sequence conservation of L19-Flavobacteria ribosomal protein leader | |
Identifiers | |
Symbol | L19-Flavobacteria |
Rfam | RF03130 |
Other data | |
RNA type | Cis-reg; leader |
SO | SO:0000837 |
PDB structures | PDBe |
L19 Ribosomal protein leaders are part of the ribosome biogenesis. They were used as an autoregulatory mechanism to control the concentration of ribosomal proteins L19. This family is a putative ribosomal protein leader autoregulatory structure[1] found in B. subtilis and other low-GC Gram-positive bacteria. It is located in the 5′ untranslated regions of mRNAs encoding ribosomal protein L19 (rplS). More examples were predicted in Flavobacteria[2] or Firmicutes[3] with bioinformatic approaches. The structures of all these predicted L19 ribosomal leaders are similar.
See also
References
- ^ Zengel JM, Lindahl L (1994). Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli. Progress in Nucleic Acid Research and Molecular Biology. Vol. 47. pp. 331–370. doi:10.1016/S0079-6603(08)60256-1. ISBN 978-0-12-540047-3. PMID 7517053.
- ^ Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi:10.1186/s12866-020-01823-6. PMC 7247131. PMID 32448158.
- ^ Yao, Z; Barrick, J; Weinberg, Z; Neph, S; Breaker, R; Tompa, M; Ruzzo, WL (2007). "A computational pipeline for high-throughput discovery of cis-regulatory noncoding RNA in prokaryotes". PLOS Computational Biology. 3 (7): e126. Bibcode:2007PLSCB...3..126Y. doi:10.1371/journal.pcbi.0030126. PMC 1913097. PMID 17616982.