MYO9B

MYO9B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5C5S, 5HPY
Identifiers
Aliases	MYO9B, CELIAC4, MYR5, myosin IXB
External IDs	OMIM: 602129; MGI: 106624; HomoloGene: 3058; GeneCards: MYO9B; OMA:MYO9B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,214,537 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,813,357 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; sural nerve; ; left testis; ; C1 segment; ; right testis; ; spleen; ; right hemisphere of cerebellum; ; ascending aorta; ; Descending thoracic aorta; ; upper lobe of left lung;
	Top expressed in
	ascending aorta; ; granulocyte; ; gastrula; ; tunica media of zone of aorta; ; internal carotid artery; ; stroma of bone marrow; ; external carotid artery; ; aortic valve; ; calvaria; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein homodimerization activity; metal ion binding; calmodulin binding; microfilament motor activity; protein binding; actin binding; cytoskeletal motor activity; ATP binding; Roundabout binding; ADP binding; GTPase activator activity; ATPase activity;
Cellular component	cytoplasm; membrane; cell cortex; actin cytoskeleton; perinuclear region of cytoplasm; cytoskeleton; myosin complex; actin filament; cytosol;
Biological process	intracellular signal transduction; ARF protein signal transduction; Roundabout signaling pathway; actin filament-based movement; positive regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction; Rho protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4650
	17925
	ENSG00000099331
	ENSMUSG00000004677
	Q13459
	Q9QY06
	NM_001130065; NM_004145
	NM_001142322; NM_001142323; NM_015742
	NP_001123537; NP_004136
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

MYO9B is a gene that encodes the Myosin-IXb protein.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099331 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004677 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bahler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (Sep 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics. 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.
^ "Entrez Gene: MYO9B myosin IXB".

Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
Wirth JA, Jensen KA, Post PL, et al. (1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail". J. Cell Sci. 109 (3): 653–61. PMID 8907710.
Post PL, Bokoch GM, Mooseker MS (1998). "Human myosin-IXb is a mechanochemically active motor and a GAP for rho". J. Cell Sci. 111 (7): 941–50. PMID 9490638.
Grewal PK, Jones AM, Maconochie M, et al. (2000). "Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing". Gene. 240 (2): 389–98. doi:10.1016/S0378-1119(99)00459-X. PMID 10580159.
Post PL, Tyska MJ, O'Connell CB, et al. (2002). "Myosin-IXb is a single-headed and processive motor". J. Biol. Chem. 277 (14): 11679–83. doi:10.1074/jbc.M111173200. PMID 11801597.
Inoue A, Saito J, Ikebe R, Ikebe M (2002). "Myosin IXb is a single-headed minus-end-directed processive motor". Nat. Cell Biol. 4 (4): 302–6. doi:10.1038/ncb774. PMID 11901422. S2CID 12158370.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Van Belzen MJ, Meijer JW, Sandkuijl LA, et al. (2003). "A major non-HLA locus in celiac disease maps to chromosome 19". Gastroenterology. 125 (4): 1032–41. doi:10.1016/S0016-5085(03)01205-8. PMID 14517787.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity". J. Biol. Chem. 280 (11): 10128–34. doi:10.1074/jbc.M413415200. PMID 15644318.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Monsuur AJ, de Bakker PI, Alizadeh BZ, et al. (2006). "Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect". Nat. Genet. 37 (12): 1341–4. doi:10.1038/ng1680. PMID 16282976. S2CID 35506194.
Kambara T, Ikebe M (2006). "A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX". J. Biol. Chem. 281 (8): 4949–57. doi:10.1074/jbc.M509141200. PMID 16338935.
Nishikawa M, Nishikawa S, Inoue A, et al. (2006). "A unique mechanism for the processive movement of single-headed myosin-IX". Biochem. Biophys. Res. Commun. 343 (4): 1159–64. doi:10.1016/j.bbrc.2006.03.057. PMID 16616011.
Amundsen SS, Monsuur AJ, Wapenaar MC, et al. (2006). "Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort". Hum. Immunol. 67 (4–5): 341–5. doi:10.1016/j.humimm.2006.03.020. PMID 16720215.
Giordano M, Marano C, Mellai M, et al. (2007). "A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population". Genes Immun. 7 (7): 606–8. doi:10.1038/sj.gene.6364331. PMID 16943798.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
van Bodegraven AA, Curley CR, Hunt KA, et al. (2007). "Genetic variation in myosin IXB is associated with ulcerative colitis". Gastroenterology. 131 (6): 1768–74. doi:10.1053/j.gastro.2006.09.011. PMID 17087940.
Núñez C, Márquez A, Varadé J, et al. (2007). "No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population". Tissue Antigens. 68 (6): 489–92. doi:10.1111/j.1399-0039.2006.00699.x. PMID 17176439.

External links

Overview of all the structural information available in the PDB for UniProt: Q13459 (Human Unconventional myosin-IXb (MYO9B)) at the PDBe-KB.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099331 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004677 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9226381-5] Bahler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (Sep 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics. 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.

[entrez-6] "Entrez Gene: MYO9B myosin IXB".

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References

Further reading

External links