NUFIP1

NUFIP1
Identifiers
Aliases	NUFIP1, NUFIP, bA540M5.1, FMR1 interacting protein 1, nuclear FMR1 interacting protein 1, Rsa1
External IDs	OMIM: 604354; MGI: 1351474; HomoloGene: 8216; GeneCards: NUFIP1; OMA:NUFIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	44,989,471 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	76,374,819 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; gonad; ; secondary oocyte; ; ventricular zone; ; testicle; ; ganglionic eminence; ; Brodmann area 23; ; gastrocnemius muscle; ; Achilles tendon; ; islet of Langerhans;
	Top expressed in
	primitive streak; ; epiblast; ; renal corpuscle; ; medullary collecting duct; ; external carotid artery; ; Gonadal ridge; ; internal carotid artery; ; Paneth cell; ; abdominal wall; ; endothelial cell of lymphatic vessel;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ATPase binding; identical protein binding; protein-macromolecule adaptor activity; snoRNA binding; RNA binding; metal ion binding; DNA binding; nucleic acid binding;
Cellular component	nuclear matrix; nucleus; pre-snoRNP complex; perichromatin fibrils; nucleolus; cytosolic ribosome; transcription elongation factor complex; fibrillar center; presynaptic active zone; protein-containing complex; synapse;
Biological process	box C/D snoRNP assembly; positive regulation of transcription by RNA polymerase II; RNA processing; protein complex oligomerization;
	Sources:Amigo / QuickGO
Orthologs
	26747
	27275
	ENSG00000083635
	ENSMUSG00000022009
	Q9UHK0
	Q9QXX8
	NM_012345
	NM_013745
	NP_036477
	NP_038773
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear fragile X mental retardation-interacting protein 1 is a protein that in humans is encoded by the NUFIP1 gene.^[5]^[6]^[7]

Interactions

NUFIP1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000083635 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022009 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Bardoni B, Schenck A, Mandel JL (Jan 2000). "A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein". Hum Mol Genet. 8 (13): 2557–66. doi:10.1093/hmg/8.13.2557. PMID 10556305.
^ Bardoni B, Giglio S, Schenck A, Rocchi M, Mandel JL (Aug 2000). "Assignment of NUFIP1 (nuclear FMRP interacting protein 1) gene to chromosome 13q14 and assignment of a pseudogene to chromosome 6q12". Cytogenet Cell Genet. 89 (1–2): 11–3. doi:10.1159/000015580. PMID 10894927.
^ "Entrez Gene: NUFIP1 nuclear fragile X mental retardation protein interacting protein 1".
^ ^a ^b Cabart P, Chew HK, Murphy S (Jul 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene. 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825.
^ Bardoni B, Castets M, Huot ME, Schenck A, Adinolfi S, Corbin F, Pastore A, Khandjian EW, Mandel JL (Jul 2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum. Mol. Genet. 12 (14): 1689–98. doi:10.1093/hmg/ddg181. PMID 12837692.

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Cabart P, Chew HK, Murphy S (2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene. 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825.
Bardoni B, Willemsen R, Weiler IJ, Schenck A, Severijnen LA, Hindelang C, Lalli E, Mandel JL (2003). "NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes". Exp. Cell Res. 289 (1): 95–107. doi:10.1016/S0014-4827(03)00222-2. PMID 12941608.
Bardoni B, Castets M, Huot ME, Schenck A, Adinolfi S, Corbin F, Pastore A, Khandjian EW, Mandel JL (2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum. Mol. Genet. 12 (14): 1689–98. doi:10.1093/hmg/ddg181. PMID 12837692.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000083635 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022009 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10556305-5] Bardoni B, Schenck A, Mandel JL (Jan 2000). "A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein". Hum Mol Genet. 8 (13): 2557–66. doi:10.1093/hmg/8.13.2557. PMID 10556305.

[pmid10894927-6] Bardoni B, Giglio S, Schenck A, Rocchi M, Mandel JL (Aug 2000). "Assignment of NUFIP1 (nuclear FMRP interacting protein 1) gene to chromosome 13q14 and assignment of a pseudogene to chromosome 6q12". Cytogenet Cell Genet. 89 (1–2): 11–3. doi:10.1159/000015580. PMID 10894927.

[entrez-7] "Entrez Gene: NUFIP1 nuclear fragile X mental retardation protein interacting protein 1".

[pmid15107825-8] Cabart P, Chew HK, Murphy S (Jul 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II". Oncogene. 23 (31): 5316–29. doi:10.1038/sj.onc.1207684. PMID 15107825.

[pmid12837692-9] Bardoni B, Castets M, Huot ME, Schenck A, Adinolfi S, Corbin F, Pastore A, Khandjian EW, Mandel JL (Jul 2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum. Mol. Genet. 12 (14): 1689–98. doi:10.1093/hmg/ddg181. PMID 12837692.

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Interactions

References

Further reading