From Wikipedia, the free encyclopedia
Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene .[ 5] [ 6] [ 7]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000141447 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044252 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport" . J Biol Chem . 276 (21): 18407–14. doi :10.1074/jbc.M101204200 PMID 11279184 . ^ Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res . 40 (12): 2204–11. PMID 10588946 . ^ a b "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A" .
Further reading
Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res . 42 (8): 1203–13. PMID 11483621 . Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains" . Genomics . 78 (3): 185–96. doi :10.1006/geno.2001.6663 . PMID 11735225 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Johansson M, Bocher V, Lehto M, et al. (2004). "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct" . Mol. Biol. Cell . 14 (3): 903–15. doi :10.1091/mbc.E02-08-0459 . PMC 151568 PMID 12631712 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Johansson M, Lehto M, Tanhuanpää K, et al. (2006). "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments" . Mol. Biol. Cell . 16 (12): 5480–92. doi :10.1091/mbc.E05-03-0189 . PMC 1289395 PMID 16176980 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .
