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TASP1

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TASP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTASP1, C20orf13, dJ585I14.2, taspase 1, SULEHS
External IDsOMIM: 608270; MGI: 1923062; HomoloGene: 9795; GeneCards: TASP1; OMA:TASP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017714
NM_001323602
NM_001323603
NM_001323604

NM_001159640
NM_001159641
NM_001289611
NM_175225

RefSeq (protein)

NP_001310531
NP_001310532
NP_001310533
NP_060184

NP_001153112
NP_001153113
NP_001276540
NP_780434

Location (UCSC)Chr 20: 13.39 – 13.64 MbChr 2: 139.68 – 139.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Threonine aspartase 1 is an enzyme that in humans is encoded by the TASP1 gene.[5][6]

Function

This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Cleavage of TFIIA has been found to drive spermatogenesis.[7]

Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

Clinical significance

Taspase1 is overexpressed in primary human cancers and functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis. Therefore, Taspase1 may serve as a novel anti-cancer therapeutic target.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089123Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039033Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hsieh JJ, Cheng EH, Korsmeyer SJ (Nov 2003). "Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression". Cell. 115 (3): 293–303. doi:10.1016/S0092-8674(03)00816-X. PMID 14636557. S2CID 18952302.
  6. ^ a b "Entrez Gene: TASP1 taspase, threonine aspartase, 1".
  7. ^ Oyama, T; Sasagawa, S; Takeda, S; Hess, R. A.; Lieberman, P. M.; Cheng, E. H.; Hsieh, J. J. (2013). "Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs". Developmental Cell. 27 (2): 188–200. doi:10.1016/j.devcel.2013.09.025. PMC 3947863. PMID 24176642.
  8. ^ Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, Lu D, Cheng EH, Hsieh JJ (July 2010). "Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis". Cancer Res. 70 (13): 5358–67. doi:10.1158/0008-5472.CAN-10-0027. PMC 2909739. PMID 20516119.

Further reading