GZMK

GZMK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MZA, 1MZD
Identifiers
Aliases	GZMK, TRYP2, granzyme K
External IDs	OMIM: 600784; MGI: 1298232; HomoloGene: 20485; GeneCards: GZMK; OMA:GZMK - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	55,034,570 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	113,362,442 bp
RNA expression pattern
	Top expressed in
	lymph node; ; granulocyte; ; spleen; ; blood; ; appendix; ; testicle; ; gallbladder; ; trabecular bone; ; epithelium of nasopharynx; ; thymus;
	Top expressed in
	tail of embryo; ; Region II of hippocampus proper; ; submandibular gland; ; supramammillary nucleus; ; medial amygdaloid nucleus; ; CA3 field; ; central amygdaloid nucleus; ; blood; ; gastrula; ; lymph node;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity;
Cellular component	extracellular region;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	3003
	14945
	ENSG00000113088
	ENSMUSG00000042385
	P49863
	O35205
	NM_002104
	NM_008196
	NP_002095
	NP_032222
	Wikidata
View/Edit Human	View/Edit Mouse

Granzyme K is a protein that in humans is encoded by the GZMK gene.^[5]^[6]

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113088 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042385 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Przetak MM, Yoast S, Schmidt BF (Jun 1995). "Cloning of cDNA for human granzyme 3". FEBS Lett. 364 (3): 268–71. doi:10.1016/0014-5793(95)00407-Z. PMID 7758581. S2CID 29315976.
^ ^a ^b "Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)".

Smyth MJ, O'Connor MD, Trapani JA (1996). "Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies". J. Leukoc. Biol. 60 (5): 555–62. doi:10.1002/jlb.60.5.555. PMID 8929545. S2CID 19732623.
Shi L, Kam CM, Powers JC, et al. (1993). "Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions". J. Exp. Med. 176 (6): 1521–9. doi:10.1084/jem.176.6.1521. PMC 2119451. PMID 1460416.
Hameed A, Lowrey DM, Lichtenheld M, Podack ER (1988). "Characterization of three serine esterases isolated from human IL-2 activated killer cells". J. Immunol. 141 (9): 3142–7. PMID 3262682.
Baker E, Sayers TJ, Sutherland GR, Smyth MJ (1994). "The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases". Immunogenetics. 40 (3): 235–7. doi:10.1007/BF00167085. PMID 8039831. S2CID 37615055.
Sayers TJ, Lloyd AR, McVicar DW, et al. (1996). "Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3". J. Leukoc. Biol. 59 (5): 763–8. doi:10.1002/jlb.59.5.763. PMID 8656064. S2CID 18065724.
Hink-Schauer C, Estébanez-Perpiñá E, Wilharm E, et al. (2003). "The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features". J. Biol. Chem. 277 (52): 50923–33. doi:10.1074/jbc.M207962200. PMID 12384499.
Fajardo I, Pejler G (2003). "Formation of active monomers from tetrameric human beta-tryptase". Biochem. J. 369 (Pt 3): 603–10. doi:10.1042/BJ20021418. PMC 1223112. PMID 12387726.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhao T, Zhang H, Guo Y, et al. (2007). "Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells". Cell Death Differ. 14 (3): 489–99. doi:10.1038/sj.cdd.4402040. PMID 17008916. S2CID 6044972.
Zhao T, Zhang H, Guo Y, Fan Z (2007). "Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death". J. Biol. Chem. 282 (16): 12104–11. doi:10.1074/jbc.M611006200. PMID 17308307.
Rucevic M, Fast LD, Jay GD, et al. (2007). "Altered levels and molecular forms of granzyme k in plasma from septic patients". Shock. 27 (5): 488–93. doi:10.1097/01.shk.0000246905.24895.e5. PMID 17438453. S2CID 525904.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113088 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042385 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7758581-5] Przetak MM, Yoast S, Schmidt BF (Jun 1995). "Cloning of cDNA for human granzyme 3". FEBS Lett. 364 (3): 268–71. doi:10.1016/0014-5793(95)00407-Z. PMID 7758581. S2CID 29315976.

[entrez-6] "Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)".

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References

Further reading