DRG1

DRG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EKI
Identifiers
Aliases	DRG1, NEDD3, developmentally regulated GTP binding protein 1
External IDs	OMIM: 603952; MGI: 1343297; HomoloGene: 3060; GeneCards: DRG1; OMA:DRG1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,530,634 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,216,415 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; male germ cell; ; triceps brachii muscle; ; glutes; ; sperm; ; deltoid muscle; ; tibialis anterior muscle; ; Skeletal muscle tissue of rectus abdominis; ; quadriceps femoris muscle;
	Top expressed in
	medial ganglionic eminence; ; spermatocyte; ; blastocyst; ; spermatid; ; morula; ; morula; ; embryo; ; epiblast; ; internal carotid artery; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; transcription factor binding; protein binding; identical protein binding; GTPase activity; microtubule binding; hydrolase activity; potassium ion binding; metal ion binding;
Cellular component	cytoplasm; polysome; membrane; cytosol; nuclear body; nucleus;
Biological process	multicellular organism development; transcription, DNA-templated; cytoplasmic translation; positive regulation of microtubule polymerization; regulation of mitotic spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	4733
	13494
	ENSG00000185721
	ENSMUSG00000020457
	Q9Y295
	P32233
	NM_004147
	NM_007879
	NP_004138
	NP_031905
	Wikidata
View/Edit Human	View/Edit Mouse

Developmentally-regulated GTP-binding protein 1 is a protein that in humans is encoded by the DRG1 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185721 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020457 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. PMID 7929244.
^ Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem Biophys Res Commun. 189 (1): 363–70. doi:10.1016/0006-291X(92)91567-A. PMID 1449490.
^ "Entrez Gene: DRG1 developmentally regulated GTP binding protein 1".

Sazuka T, Kinoshita M, Tomooka Y, et al. (1992). "Expression of DRG during murine embryonic development". Biochem. Biophys. Res. Commun. 189 (1): 371–7. doi:10.1016/0006-291X(92)91568-B. PMID 1280421.
Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. 12 (11): 2343–50. PMID 8649774.
Zhao XF, Aplan PD (1999). "SCL binds the human homologue of DRG in vivo". Biochim. Biophys. Acta. 1448 (1): 109–14. doi:10.1016/s0167-4889(98)00129-3. PMID 9824680.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins". Biochim. Biophys. Acta. 1491 (1–3): 196–204. doi:10.1016/s0167-4781(00)00025-7. PMID 10760581.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bandyopadhyay S, Pai SK, Gross SC, et al. (2003). "The Drg-1 gene suppresses tumor metastasis in prostate cancer". Cancer Res. 63 (8): 1731–6. PMID 12702552.
Bandyopadhyay S, Pai SK, Hirota S, et al. (2004). "Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression". Oncogene. 23 (33): 5675–81. doi:10.1038/sj.onc.1207734. PMID 15184886.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Bandyopadhyay S, Wang Y, Zhan R, et al. (2007). "The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer". Cancer Res. 66 (24): 11983–90. doi:10.1158/0008-5472.CAN-06-0943. PMID 17178897.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185721 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020457 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7929244-5] Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. PMID 7929244.

[pmid1449490-6] Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem Biophys Res Commun. 189 (1): 363–70. doi:10.1016/0006-291X(92)91567-A. PMID 1449490.

[entrez-7] "Entrez Gene: DRG1 developmentally regulated GTP binding protein 1".

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References

Further reading