PAIP1

PAIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JH4, 3NTW, 3RK6
Identifiers
Aliases	PAIP1, poly(A) binding protein interacting protein 1
External IDs	OMIM: 605184; MGI: 2384993; HomoloGene: 4709; GeneCards: PAIP1; OMA:PAIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	43,557,758 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	119,594,754 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; muscle of thigh; ; gastrocnemius muscle; ; islet of Langerhans; ; smooth muscle tissue; ; left ventricle; ; endometrium; ; skeletal muscle tissue; ; C1 segment;
	Top expressed in
	zygote; ; secondary oocyte; ; spermatocyte; ; primary oocyte; ; ventricular zone; ; retinal pigment epithelium; ; genital tubercle; ; muscle of thigh; ; ciliary body; ; pineal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation activator activity; protein binding; RNA binding;
Cellular component	cytoplasm; cytosol;
Biological process	translational initiation; mRNA stabilization; regulation of translation; positive regulation of translation; regulation of translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	10605
	218693
	ENSG00000172239
	ENSMUSG00000025451
	Q9H074
	Q8VE62
	NM_006451; NM_182789; NM_183323
	NM_001079849; NM_145457
	NP_006442; NP_877590; NP_899152
	NP_001073318; NP_663432
	Wikidata
View/Edit Human	View/Edit Mouse

Polyadenylate-binding protein-interacting protein 1 is a protein that in humans is encoded by the PAIP1 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.^[7]

Interactions

PAIP1 has been shown to interact with PABPC1.^[5]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172239 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025451 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Craig AW, Haghighat A, Yu AT, Sonenberg N (Apr 1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation". Nature. 392 (6675): 520–3. doi:10.1038/33198. PMID 9548260. S2CID 10891925.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ ^a ^b "Entrez Gene: PAIP1 poly(A) binding protein interacting protein 1".
^ Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N (Jun 2002). "Paip1 interacts with poly(A) binding protein through two independent binding motifs". Mol. Cell. Biol. 22 (11): 3769–82. doi:10.1128/MCB.22.11.3769-3782.2002. PMC 133836. PMID 11997512.

Gray NK, Coller JM, Dickson KS, Wickens M (2000). "Multiple portions of poly(A)-binding protein stimulate translation in vivo". EMBO J. 19 (17): 4723–33. doi:10.1093/emboj/19.17.4723. PMC 302064. PMID 10970864.
Grosset C, Chen CY, Xu N, Sonenberg N, Jacquemin-Sablon H, Shyu AB (2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex". Cell. 103 (1): 29–40. doi:10.1016/S0092-8674(00)00102-1. PMID 11051545. S2CID 18135412.
Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N (2001). "Translational repression by a novel partner of human poly(A) binding protein, Paip2". Mol. Cell. 7 (1): 205–16. doi:10.1016/S1097-2765(01)00168-X. PMID 11172725.
Deo RC, Sonenberg N, Burley SK (2001). "X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4414–9. doi:10.1073/pnas.071552198. PMC 31849. PMID 11287654.
Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N (2002). "Paip1 interacts with poly(A) binding protein through two independent binding motifs". Mol. Cell. Biol. 22 (11): 3769–82. doi:10.1128/MCB.22.11.3769-3782.2002. PMC 133836. PMID 11997512.
Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM (2004). "Lineage-specific gene duplication and loss in human and great ape evolution". PLOS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172239 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025451 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9548260-5] Craig AW, Haghighat A, Yu AT, Sonenberg N (Apr 1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation". Nature. 392 (6675): 520–3. doi:10.1038/33198. PMID 9548260. S2CID 10891925.

[pmid11230166-6] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-7] "Entrez Gene: PAIP1 poly(A) binding protein interacting protein 1".

[pmid11997512-8] Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N (Jun 2002). "Paip1 interacts with poly(A) binding protein through two independent binding motifs". Mol. Cell. Biol. 22 (11): 3769–82. doi:10.1128/MCB.22.11.3769-3782.2002. PMC 133836. PMID 11997512.

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Function

Interactions

References

Further reading