OSCAR (gene)

OSCAR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EIV, 5EIQ, 5CJB, 5CJ8
Identifiers
Aliases	OSCAR, PIGR3, PIgR-3, osteoclast associated, immunoglobulin-like receptor, osteoclast associated Ig-like receptor
External IDs	OMIM: 606862; MGI: 2179720; HomoloGene: 77042; GeneCards: OSCAR; OMA:OSCAR - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,102,692 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,619,156 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; spleen; ; upper lobe of left lung; ; right lung; ; bone marrow; ; bone marrow cells; ; gonad; ; appendix;
	Top expressed in
	morula; ; embryo; ; embryo; ; body of femur; ; spermatocyte; ; superior frontal gyrus; ; primary visual cortex; ; secondary oocyte; ; neural layer of retina; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	collagen receptor activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; extracellular exosome; membrane; specific granule lumen; tertiary granule lumen;
Biological process	regulation of immune response; neutrophil degranulation; osteoclast differentiation; collagen-activated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	126014
	232790
ENSG00000277088; ENSG00000170909; ENSG00000274703; ENSG00000276982; ENSG00000278533;
	ENSG00000275736; ENSG00000275551; ENSG00000278378; ENSG00000273511; ENSG00000275644
	ENSMUSG00000054594
	Q8IYS5
	Q8VBT3
NM_001282349; NM_001282350; NM_130771; NM_133168; NM_133169;
	NM_206817; NM_206818
	NM_001290377; NM_175632
NP_001269278; NP_001269279; NP_570127; NP_573398; NP_573399;
	NP_996554
	NP_001277306; NP_783440
	Wikidata
View/Edit Human	View/Edit Mouse

Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene.^[5]^[6]

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[6]

References

^ ^a ^b ^c ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 GRCh38: Ensembl release 89: ENSG00000277088, ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054594 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim N, Takami M, Rho J, Josien R, Choi Y (Jan 2002). "A novel member of the leukocyte receptor complex regulates osteoclast differentiation". J Exp Med. 195 (2): 201–9. doi:10.1084/jem.20011681. PMC 2193610. PMID 11805147.
^ ^a ^b "Entrez Gene: OSCAR osteoclast-associated receptor".

Pupello DF, Lipton M, Shumway NE (1976). "An unusual case of a bullet embolus". The Journal of the Florida Medical Association. 62 (11): 51. PMID 1185147.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Merck E, Gaillard C, Gorman DM, et al. (2004). "OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells". Blood. 104 (5): 1386–95. doi:10.1182/blood-2004-03-0850. PMID 15155468.
Merck E, de Saint-Vis B, Scuiller M, et al. (2005). "Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses". Blood. 105 (9): 3623–32. doi:10.1182/blood-2004-07-2809. PMID 15650060.
Tenca C, Merlo A, Merck E, et al. (2005). "CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells". J. Immunol. 174 (11): 6757–63. doi:10.4049/jimmunol.174.11.6757. PMID 15905516.
Kim GS, Koh JM, Chang JS, et al. (2005). "Association of the OSCAR promoter polymorphism with BMD in postmenopausal women". J. Bone Miner. Res. 20 (8): 1342–8. doi:10.1359/JBMR.050320. PMID 16007331. S2CID 23162197.
Kim K, Kim JH, Lee J, et al. (2005). "Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis". J. Biol. Chem. 280 (42): 35209–16. doi:10.1074/jbc.M505815200. PMID 16109714.
Merck E, Gaillard C, Scuiller M, et al. (2006). "Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils". J. Immunol. 176 (5): 3149–56. doi:10.4049/jimmunol.176.5.3149. PMID 16493074.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 GRCh38: Ensembl release 89: ENSG00000277088, ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054594 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11805147-5] Kim N, Takami M, Rho J, Josien R, Choi Y (Jan 2002). "A novel member of the leukocyte receptor complex regulates osteoclast differentiation". J Exp Med. 195 (2): 201–9. doi:10.1084/jem.20011681. PMC 2193610. PMID 11805147.

[entrez-6] "Entrez Gene: OSCAR osteoclast-associated receptor".

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References

Further reading