DNA damage-binding protein
| damage-specific DNA binding protein 1, 127kDa | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | DDB1 | ||||||
| Alt. symbols | XPE | ||||||
| NCBI gene | 1642 | ||||||
| HGNC | 2717 | ||||||
| OMIM | 600045 | ||||||
| RefSeq | NM_001923 | ||||||
| UniProt | Q16531 | ||||||
| Other data | |||||||
| Locus | Chr. 11 q12-q13 | ||||||
| |||||||
| damage-specific DNA binding protein 2, 48kDa | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | DDB2 | ||||||
| Alt. symbols | DBB, UV-DDB2, FLJ34321 | ||||||
| NCBI gene | 1643 | ||||||
| HGNC | 2718 | ||||||
| OMIM | 600811 | ||||||
| RefSeq | NM_000107 | ||||||
| UniProt | Q92466 | ||||||
| Other data | |||||||
| Locus | Chr. 11 p12-p11 | ||||||
| |||||||
DNA damage-binding protein or UV-DDB[1] is a protein complex that is responsible for repair of UV-damaged DNA.[2] This complex is composed of two protein subunits, a large subunit DDB1 (p127) and a small subunit DDB2 (p48). When cells are exposed to UV radiation, DDB1 moves from the cytosol to the nucleus and binds to DDB2, thus forming the UV-DDB complex. This complex functions in nucleotide excision repair, recognising UV-induced (6-4) pyrimidine-pyrimidone photoproducts and cyclobutane pyrimidine dimers.[1]
References
- ^ a b Iovine, Barbara; Iannella, Maria Luigia; Bevilacqua, Maria Assunta (2011). "Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions". The International Journal of Biochemistry & Cell Biology. 43 (12). Elsevier: 1664–1667. doi:10.1016/j.biocel.2011.09.001. PMID 21959250.
- ^ Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (Feb 1996). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics. 29 (1): 62–9. doi:10.1006/geno.1995.1215. PMID 8530102.
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