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Damage-specific DNA binding protein 2, 48kDa
Protein DDB2 PDB 3EI4.png
Rendering based on PDB 3EI4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DDB2 ; DDBB; UV-DDB2
External IDs OMIM600811 MGI1355314 HomoloGene83 GeneCards: DDB2 Gene
RNA expression pattern
PBB GE DDB2 203409 at tn.png
More reference expression data
Species Human Mouse
Entrez 1643 107986
Ensembl ENSG00000134574 ENSMUSG00000002109
UniProt Q92466 Q99J79
RefSeq (mRNA) NM_000107 NM_028119
RefSeq (protein) NP_000098 NP_082395
Location (UCSC) Chr 11:
47.21 – 47.24 Mb
Chr 2:
91.21 – 91.24 Mb
PubMed search [1] [2]

DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene.[1][2]


DDB2 is the smaller subunit of a heterodimeric protein implicated in the etiology of xeroderma pigmentosum group E. This subunit appears to be required for DNA binding.[3]


DDB2 has been shown to interact with CUL4A,[4] CUL4B[4] and DDB1.[4][5][6] Also, some researches about DDB2 show a relationship between DDB2 and PARP1.PARP1 as a novel DDB2-associated factor,which may help to recruitment a chromatin-remodeling enzyme,named ALC1.[7]


  1. ^ Keeney S, Chang GJ, Linn S (Oct 1993). "Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E". The Journal of Biological Chemistry 268 (28): 21293–300. PMID 8407967. 
  2. ^ Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (Sep 1995). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics 29 (1): 62–9. doi:10.1006/geno.1995.1215. PMID 8530102. 
  3. ^ "Entrez Gene: DDB2 damage-specific DNA binding protein 2, 48kDa". 
  4. ^ a b c Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapić-Otrin V (Jul 2008). "The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A". Cancer Research 68 (13): 5014–22. doi:10.1158/0008-5472.CAN-07-6162. PMID 18593899. 
  5. ^ Bergametti F, Sitterlin D, Transy C (Jul 2002). "Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex". Journal of Virology 76 (13): 6495–501. doi:10.1128/JVI.76.13.6495-6501.2002. PMC 136256. PMID 12050362. 
  6. ^ Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863. 
  7. ^ Pines A, Vrouwe MG, Marteijn JA, Typas D, Luijsterburg MS, Cansoy M, Hensbergen P, Deelder A, de Groot A, Matsumoto S, Sugasawa K, Thoma N, Vermeulen W, Vrieling H, Mullenders L (Oct 2012). "PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1". The Journal of Cell Biology 199 (2): 235–49. doi:10.1083/jcb.201112132. PMID 23045548. 

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