TSHZ1

TSHZ1
Identifiers
Aliases	TSHZ1, CAA, NY-CO-33, SDCCAG33, TSH1, teashirt zinc finger homeobox 1
External IDs	OMIM: 614427; MGI: 1346031; HomoloGene: 4227; GeneCards: TSHZ1; OMA:TSHZ1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	75,289,950 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	84,105,831 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; cerebellar vermis; ; mucosa of ileum; ; Brodmann area 23; ; endothelial cell; ; pancreatic epithelial cell; ; primary visual cortex; ; caput epididymis; ; middle temporal gyrus; ; myocardium of left ventricle;
	Top expressed in
	Rostral migratory stream; ; olfactory bulb; ; olfactory epithelium; ; migratory enteric neural crest cell; ; cumulus cell; ; zygote; ; abdominal wall; ; vestibular membrane of cochlear duct; ; ciliary body; ; olfactory tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; metal ion binding; chromatin binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	soft palate development; regulation of gene expression; regulation of transcription, DNA-templated; transcription, DNA-templated; anterior/posterior pattern specification; middle ear morphogenesis; multicellular organism development; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10194
	110796
	ENSG00000179981
	ENSMUSG00000046982
	Q6ZSZ6
	Q5DTH5
	NM_001308210; NM_005786
	NM_001081300; NM_001364993; NM_001364994
	NP_001295139; NP_005777; NP_005777.3
	NP_001074769; NP_001351922; NP_001351923
	Wikidata
View/Edit Human	View/Edit Mouse

Teashirt zinc finger homeobox 1 is a protein that in humans is encoded by the TSHZ1 gene.^[5]

Function

This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179981 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046982 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Teashirt zinc finger homeobox 1".

Schick B, Wemmert S, Willnecker V, Dlugaiczyk J, Nicolai P, Siwiec H, Thiel CT, Rauch A, Wendler O (November 2011). "Genome-wide copy number profiling using a 100K SNP array reveals novel disease-related genes BORIS and TSHZ1 in juvenile angiofibroma". International Journal of Oncology. 39 (5): 1143–51. doi:10.3892/ijo.2011.1166. PMID 21874228.
Kajiwara Y, Akram A, Katsel P, Haroutunian V, Schmeidler J, Beecham G, Haines JL, Pericak-Vance MA, Buxbaum JD (2009). Bush AI (ed.). "FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4". PLOS ONE. 4 (4): e5071. doi:10.1371/journal.pone.0005071. PMC 2660419. PMID 19343227.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
Coré N, Caubit X, Metchat A, Boned A, Djabali M, Fasano L (August 2007). "Tshz1 is required for axial skeleton, soft palate and middle ear development in mice". Developmental Biology. 308 (2): 407–20. doi:10.1016/j.ydbio.2007.05.038. PMID 17586487.
Feenstra I, Vissers LE, Pennings RJ, Nillessen W, Pfundt R, Kunst HP, Admiraal RJ, Veltman JA, van Ravenswaaij-Arts CM, Brunner HG, Cremers CW (December 2011). "Disruption of teashirt zinc finger homeobox 1 is associated with congenital aural atresia in humans". American Journal of Human Genetics. 89 (6): 813–9. doi:10.1016/j.ajhg.2011.11.008. PMC 3234381. PMID 22152683.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179981 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046982 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Teashirt zinc finger homeobox 1".

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Function

References

Further reading