Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4gene.[3][4]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.[4]
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Hillig RC, Coulie PG, Stroobant V, et al. (2001). "High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene". J. Mol. Biol. 310 (5): 1167–76. doi:10.1006/jmbi.2001.4816. PMID11502003.
Hudolin T, Juretic A, Spagnoli GC, et al. (2006). "Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in cancerous and benign prostatic tissue". Prostate. 66 (1): 13–8. doi:10.1002/pros.20312. PMID16114059.
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