List of U.S. Routes in Mississippi
   Standard route shields | |
| Highway names | |
|---|---|
| Interstates | Interstate X (I-X) |
| US Highways | U.S. Route X (US X) |
| System links | |
In the U.S. state of Mississippi, U.S. Routes are maintained by the Mississippi Department of Transportation (MDOT).
Mainline highways
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 US 11
|
173.1 | 278.6 | I-59 at Nicholson | US 11 at Alabama state line near Kewanee | 1926 | current | ||
 US 45
|
— | — | US 45 at Alabama state line near State Line | US 45 at Tennessee state line near Wenesoga | 1926 | current | ||
 US 49
|
— | — | US 90 at Gulfport | US 49E/US 49W at Yazoo City | 1926 | current | Southern segment | |
| US 49
|
— | — | US 49E/US 49W at Tutwiler | US 49 at Arkansas state line (Helena Bridge) near Helena | 1926 | current | Northern segment | |
 US 49E
|
85.862 | 138.181 | US 49 & US 49W at Yazoo City | US 49 & US 49W at Tutwiler | — | — | ||
 US 49W
|
81.894 | 131.796 | US 49 & US 49E at Yazoo City | US 49 & US 49E at Tutwiler | — | — | ||
 US 51
|
— | — | US 51 at Louisiana state line near Osyka | US 51 at Tennessee state line near Horn Lake | 1926 | current | ||
 US 61
|
— | — | US 61 at Louisiana state line near Woodville | US 61 at Tennessee state line near Lake View | 1926 | current | ||
 US 72
|
— | — | US 72 at Tennessee state line near Barton | US 72 at the Alabama state line near Oldham | 1926 | current | ||
 US 78
|
118.0 | 189.9 | US 78 at Tennessee state line near Olive Branch | US 78 at Alabama state line near Tremont | 1926 | current | ||
 US 80
|
157 | 253 | US 80 at Louisiana state line (Vicksburg Bridge) near Vicksburg | US 80 at Alabama state line near Kewanee | 1926 | current | ||
 US 82
|
180.0 | 289.7 | US 82 at Arkansas state line (Greenville Bridge) near Refuge | US 82 at Alabama state line near New Hope | 1932 | current | ||
 US 84
|
— | — | US 84 at Louisiana state line (Natchez-Vidalia Bridge) near Natchez | US 84 at Alabama state line near Waynesboro | 1926 | current | ||
 US 90
|
75 | 121 | US 90 at Louisiana state line (East Pearl River) near Pearlington | US 90 at Alabama state line near Pecan | 1926 | current | ||
 US 98
|
— | — | US 61 at Washington | US 98 at Alabama state line near Lucedale | 1933 | current | ||
 US 278
|
— | — | US 278 at Arkansas state line (Greenville Bridge) near Refuge | US 278 at Alabama state line near Gattman | 1978 | current | ||
 US 425
|
2.9 | 4.7 | US 61 at Natchez, Mississippi | US 425 at Louisiana state line (Natchez-Vidalia Bridge) near Natchez | 2005 | current | ||
Special routes
 |
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 US 45 Alt.
|
62.9 | 101.2 | US 45 in Brooksville | US 45/US 278 in Shannon | 1968 | current | Signed as both US 45A and US 45 Alternate | |
 US 61 Bus.
|
— | — | US 61 south of Vicksburg | US 61 north of Vicksburg | — | — | ||
