Medronic acid

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Not to be confused with mildronate or minodronate.
Medronic acid
Names
IUPAC name
methanediylbis(phosphonic acid)
Other names
methanediphosphonic acid; methylenebis(phosphonic acid); methylene diphosphonate; medronate; phosphonomethylphosphonic acid; MDP
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.016.229 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) checkY
    Key: MBKDYNNUVRNNRF-UHFFFAOYSA-N checkY
  • O=P(O)(O)CP(=O)(O)O
Properties
CH6O6P2
Molar mass 176.001 g·mol−1
Melting point 199 to 200 °C (390 to 392 °F; 472 to 473 K)[1]
Hazards
Lethal dose or concentration (LD, LC):
45-50 mg/kg (i.v., mice, rabbits)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Medronic acid (conjugate base, medronate), also known as methylene diphosphonate, is the smallest bisphosphonate. Its complex with radioactive technetium, 99mTc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.

References

  1. ^ a b Budavari, Susan, ed. (1996), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.), Merck, ISBN 0911910123


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