Technetium (99mTc) medronic acid

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Technetium (99mTc) medronic acid
Tc-99m medronic acid skeletal.svg
Clinical data
Routes of
administration
intravenous
ATC code
Identifiers
PubChem CID
Chemical and physical data
Formula CH6O6P2 • x99mTc
Molar mass unknown
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Technetium (99mTc) medronic acid (MDP) is a pharmaceutical product used in nuclear medicine to localize bone metastases[1] as well as other diseases that can alter the natural turn-over in the bone by bone scintigraphy.[2]

Chemistry[edit]

The drug is a complex of medronic acid, the simplest bisphosphonate, with technetium-99m (99mTc), a radionuclide that emits gamma rays. The exact structure of the complex is not known.[2][3]

Manufacture[edit]

99mTc-MDP must be prepared in a radiopharmacy. It is usually supplied as a "cold kit" to which radioactive 99mTc from a generator is added. Kit composition may vary between suppliers, but contents typically includes medronic acid, stannous chloride dihydrate and sometimes ascorbic acid.[4] Pertechnetate, eluted from the generator is added to the kit vial, which is swirled and left to stand. The labelling efficiency, an indication of how much 99mTc remains in pertechnetate form rather than bound to the MDP, can be measured using chromatography.[5][6][7][8]

References[edit]

  1. ^ Uematsu, T; Yuen, S; Yukisawa, S; Aramaki, T; Morimoto, N; Endo, M; Furukawa, H; Uchida, Y; Watanabe, J (2005). "Comparison of FDG PET and SPECT for detection of bone metastases in breast cancer". AJR Am J Roentgenol. 184 (4): 1266–73. doi:10.2214/ajr.184.4.01841266. PMID 15788608.
  2. ^ a b FDA Label: MDP Multidose Utilipack
  3. ^ KEGG Drug: D02029
  4. ^ "List of labelling kits for the preparation of a technetium-99m labelled bone scanning agent". Human Health Campus. IAEA. Retrieved 3 March 2017.
  5. ^ "MDP Bracco" (PDF). Bracco Diagnostics. Retrieved 3 March 2017.
  6. ^ "Kit for the Preparation of Technetium Tc 99m Medronate for Injection" (PDF). Pharmalucence. Retrieved 3 March 2017.
  7. ^ "TechneScan MDP Kit for the Preparation of Technetium Tc 99m Medronate Package Insert" (PDF). Mallinckrodt Medical. Retrieved 3 March 2017.
  8. ^ Mather, SJ; Ellison, D (May 1990). "Reduction-mediated technetium-99m labeling of monoclonal antibodies". Journal of Nuclear Medicine. 31 (5): 692–7. PMID 2341907.