AZIN2

AZIN2
Identifiers
Aliases	AZIN2, ADC, AZI2, ODC-p, ODC1L, ODCp, AZIB1, antizyme inhibitor 2
External IDs	OMIM: 608353; MGI: 2442093; HomoloGene: 62172; GeneCards: AZIN2; OMA:AZIN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	33,123,492 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	128,856,235 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; C1 segment; ; prefrontal cortex; ; corpus callosum; ; Brodmann area 9; ; right frontal lobe; ; substantia nigra; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	seminiferous tubule; ; spermatid; ; lumbar spinal ganglion; ; dentate gyrus of hippocampal formation granule cell; ; lens; ; spermatocyte; ; primary visual cortex; ; superior frontal gyrus; ; Rostral migratory stream; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	putrescine transmembrane transporter activity; catalytic activity; protein binding; ornithine decarboxylase activator activity; arginine decarboxylase activity; ornithine decarboxylase activity;
Cellular component	transport vesicle; cytoplasm; mitochondrion; trans-Golgi network; cell projection; Golgi apparatus; nucleus; axon; granular vesicle; membrane; dendrite; perinuclear region of cytoplasm; cis-Golgi network; cytoplasmic vesicle; perikaryon; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum-Golgi intermediate compartment; cytosol;
Biological process	positive regulation of polyamine transmembrane transport; spermatogenesis; putrescine transport; ornithine metabolic process; putrescine biosynthetic process from ornithine; trans-Golgi network membrane organization; agmatine biosynthetic process; positive regulation of catalytic activity; polyamine biosynthetic process; negative regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	113451
	242669
	ENSG00000142920
	ENSMUSG00000028789
	Q96A70
	Q8BVM4
NM_001293562; NM_001301823; NM_001301824; NM_001301825; NM_001301826;
	NM_052998; NM_001350398; NM_001350399; NM_001350400; NM_001350401; NM_001350402; NM_001376722; NM_001376724; NM_001376725; NM_001376727; NM_001376729; NM_001376730; NM_001376732
	NM_001301841; NM_172875
NP_001280491; NP_001288752; NP_001288753; NP_001288754; NP_001288755;
	NP_443724; NP_001337327; NP_001337328; NP_001337329; NP_001337330; NP_001337331; NP_001363651; NP_001363653; NP_001363654; NP_001363656; NP_001363658; NP_001363659; NP_001363661
	NP_001288770; NP_766463
	Wikidata
View/Edit Human	View/Edit Mouse

Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene.^[5]^[6]^[7] In contrast to initial suggestions,^[5] Antizyme inhibitor 2 does not act as arginine decarboxylase (ADC) in mammalian cells ^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142920 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028789 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Pitkänen LT, Heiskala M, Andersson LC (October 2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochemical and Biophysical Research Communications. 287 (5): 1051–1057. doi:10.1006/bbrc.2001.5703. PMID 11587527.
^ Zhu MY, Iyo A, Piletz JE, Regunathan S (January 2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochimica et Biophysica Acta (BBA) - General Subjects. 1670 (2): 156–164. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.
^ "Entrez Gene: ADC arginine decarboxylase".
^ Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF). The Biochemical Journal. 409 (1): 187–192. doi:10.1042/BJ20071004. PMID 17900240.
^ López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". The Journal of Biological Chemistry. 281 (41): 30896–30906. doi:10.1074/jbc.M602840200. PMID 16916800.

External links

Human AZI2 genome location and AZI2 gene details page in the UCSC Genome Browser.
Human AZIN2 genome location and AZIN2 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142920 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028789 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11587527-5] Pitkänen LT, Heiskala M, Andersson LC (October 2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochemical and Biophysical Research Communications. 287 (5): 1051–1057. doi:10.1006/bbrc.2001.5703. PMID 11587527.

[pmid14738999-6] Zhu MY, Iyo A, Piletz JE, Regunathan S (January 2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochimica et Biophysica Acta (BBA) - General Subjects. 1670 (2): 156–164. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.

[entrez-7] "Entrez Gene: ADC arginine decarboxylase".

[pmid17900240-8] Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF). The Biochemical Journal. 409 (1): 187–192. doi:10.1042/BJ20071004. PMID 17900240.

[pmid16916800-9] López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". The Journal of Biological Chemistry. 281 (41): 30896–30906. doi:10.1074/jbc.M602840200. PMID 16916800.

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References

Further reading

External links