ALG14

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ALG14
Identifiers
Aliases ALG14, CMS15, UDP-N-acetylglucosaminyltransferase subunit
External IDs MGI: 1914039 HomoloGene: 49751 GeneCards: ALG14
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001305242
NM_144988

NM_024178

RefSeq (protein)

NP_001292171
NP_659425

NP_077140.1
NP_077140

Location (UCSC) Chr 1: 94.97 – 95.07 Mb Chr 3: 121.29 – 121.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

UDP-N-acetylglucosamine transferase subunit ALG14 homolog is a protein that in humans is encoded by the ALG14 gene.[3][4]

Asparagine (N)-glycosylation is an essential modification that regulates protein folding and stability. ALG13 and ALG14 (this protein) constitute the UDP-GlcNAc transferase, which catalyzes a key step in endoplasmic reticulum N-linked glycosylation.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: asparagine-linked glycosylation 14 homolog (S. cerevisiae)". 
  4. ^ Chantret I, Dancourt J, Barbat A, Moore SE (March 2005). "Two proteins homologous to the N- and C-terminal domains of the bacterial glycosyltransferase Murg are required for the second step of dolichyl-linked oligosaccharide synthesis in Saccharomyces cerevisiae". J. Biol. Chem. 280 (10): 9236–42. doi:10.1074/jbc.M413941200. PMID 15615718. 
  5. ^ Averbeck N, Keppler-Ross S, Dean N (October 2007). "Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit". J. Biol. Chem. 282 (40): 29081–8. doi:10.1074/jbc.M704410200. PMID 17686769. 

External links[edit]

Further reading[edit]