APBA2BP

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NECAB3
Identifiers
Aliases NECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3
External IDs MGI: 1861721 HomoloGene: 10992 GeneCards: 63941
RNA expression pattern
PBB GE APBA2BP 210720 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031231
NM_031232

NM_021546

RefSeq (protein)

NP_112508.3
NP_112509.3

NP_067521.2

Location (UCSC) Chr 20: 33.66 – 33.67 Mb Chr 2: 154.54 – 154.56 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[1][2]

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[2]

References[edit]

  1. ^ Lee DS, Tomita S, Kirino Y, Suzuki T (Aug 2000). "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J Biol Chem 275 (30): 23134–8. doi:10.1074/jbc.C000302200. PMID 10833507. 
  2. ^ a b "Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein". 

Further reading[edit]