APLP1

APLP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PMR, 3Q7G, 3Q7L, 3QMK, 4RD9, 4RDA
Identifiers
Aliases	APLP1, APLP, amyloid beta precursor like protein 1
External IDs	OMIM: 104775; MGI: 88046; HomoloGene: 68447; GeneCards: APLP1; OMA:APLP1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.12 Start 35,867,899 bp End 35,879,792 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B1|7 18.32 cM Start 30,134,407 bp End 30,144,960 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment inferior olivary nucleus middle frontal gyrus right frontal lobe prefrontal cortex caudate nucleus nucleus accumbens dorsal motor nucleus of vagus nerve amygdala hypothalamus Top expressed in nucleus accumbens nucleus of stria terminalis piriform cortex molar subiculum olfactory tubercle central gray substance of midbrain globus pallidus primary visual cortex superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function alpha-2C adrenergic receptor binding heparin binding alpha-2B adrenergic receptor binding metal ion binding protein binding alpha-2A adrenergic receptor binding identical protein binding transition metal ion binding Cellular component cytoplasm integral component of membrane membrane plasma membrane basement membrane perinuclear region of cytoplasm Biological process endocytosis nervous system development cellular response to norepinephrine stimulus cell adhesion animal organ morphogenesis apoptotic process negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 333 11803 Ensembl ENSG00000105290 ENSMUSG00000006651 UniProt P51693 Q03157 RefSeq (mRNA) NM_005166 NM_001024807 NM_007467 RefSeq (protein) NP_001019978 NP_005157 NP_031493 Location (UCSC) Chr 19: 35.87 – 35.88 Mb Chr 7: 30.13 – 30.14 Mb PubMed search
Wikidata
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Amyloid-like protein 1, also known as APLP1, is a protein that in humans is encoded by the APLP1 gene. APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis.

Function

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.

Further reading

• Bayer TA, Cappai R, Masters CL, et al. (2000). "It all sticks together--the APP-related family of proteins and Alzheimer's disease". Mol. Psychiatry. 4 (6): 524–8. doi:10.1038/sj.mp.4000552. PMID 10578233.
• Kim TW, Wu K, Xu JL, et al. (1996). "Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density". Brain Res. Mol. Brain Res. 32 (1): 36–44. doi:10.1016/0169-328X(95)00328-P. PMID 7494461.
• Bush AI, Pettingell WH, de Paradis M, et al. (1994). "The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily". J. Biol. Chem. 269 (43): 26618–21. PMID 7929392.
• Wasco W, Brook JD, Tanzi RE (1993). "The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19". Genomics. 15 (1): 237–9. doi:10.1006/geno.1993.1047. PMID 8432545.
• Bressler SL, Gray MD, Sopher BL, et al. (1997). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein". Hum. Mol. Genet. 5 (10): 1589–98. doi:10.1093/hmg/5.10.1589. PMID 8894693.
• Paliga K, Peraus G, Kreger S, et al. (1998). "Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid". Eur. J. Biochem. 250 (2): 354–63. doi:10.1111/j.1432-1033.1997.0354a.x. PMID 9428684.
• Lenkkeri U, Kestilä M, Lamerdin J, et al. (1998). "Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1". Hum. Genet. 102 (2): 192–6. doi:10.1007/s004390050676. PMID 9521588.
• McNamara MJ, Ruff CT, Wasco W, et al. (1998). "Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains". Brain Res. 804 (1): 45–51. doi:10.1016/S0006-8993(98)00653-2. PMID 9729270.
• Tomita S, Ozaki T, Taru H, et al. (1999). "Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein". J. Biol. Chem. 274 (4): 2243–54. doi:10.1074/jbc.274.4.2243. PMID 9890987.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Homayouni R, Rice DS, Sheldon M, Curran T (1999). "Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1". J. Neurosci. 19 (17): 7507–15. PMID 10460257.
• Simons A, Ruppert T, Schmidt C, et al. (2002). "Evidence for a copper-binding superfamily of the amyloid precursor protein". Biochemistry. 41 (30): 9310–20. doi:10.1021/bi0258647. PMID 12135352.
• Scheinfeld MH, Ghersi E, Laky K, et al. (2003). "Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription". J. Biol. Chem. 277 (46): 44195–201. doi:10.1074/jbc.M208110200. PMID 12228233.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Walsh DM, Fadeeva JV, LaVoie MJ, et al. (2003). "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins". Biochemistry. 42 (22): 6664–73. doi:10.1021/bi027375c. PMID 12779321.
• Yamakami M, Yoshimori T, Yokosawa H (2004). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". J. Biol. Chem. 278 (52): 52865–72. doi:10.1074/jbc.M306740200. PMID 14563850.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Adlerz L, Beckman M, Holback S, et al. (2004). "Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction". Brain Res. Mol. Brain Res. 119 (1): 62–72. doi:10.1016/j.molbrainres.2003.08.014. PMID 14597230.
• Li Q, Südhof TC (2004). "Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1". J. Biol. Chem. 279 (11): 10542–50. doi:10.1074/jbc.M310001200. PMID 14699153.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Eggert S, Paliga K, Soba P, et al. (2004). "The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation". J. Biol. Chem. 279 (18): 18146–56. doi:10.1074/jbc.M311601200. PMID 14970212.{{cite journal}}: CS1 maint: unflagged free DOI (link)