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AS04 (Aka. "Adjuvant System 04") is a trade name for combination of adjuvants used in various vaccine product by GlaxoSmithKline (GSK), in particular the Fendrix Hepatitis B vaccine. It consists of aluminum hydroxide and monophosphoryl lipid A (MPL). Furthermore, it is the successor of AS03 which is a Squalene based adjuvant approved for pandemic vaccine by the EMA.[1]


  1. ^ Plotkin; et al. Vaccines 6th ed. Elsevier Saunders. pp. 58–79. ISBN 978-1-4557-0090-5. 

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