Autophagy protein 5
Template:PBB Autophagy protein 5 is a protein that in humans is encoded by the ATG5 gene.[1][2][3][4] It is an E3 ubiquitin ligase which is necessary for autophagy due to its role in autophagosome elongation. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II.
References
- ^ Hammond EM, Brunet CL, Johnson GD, Parkhill J, Milner AE, Brady G, Gregory CD, Grand RJ (May 1998). "Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast". FEBS Lett. 20 (3): 391–5. doi:10.1016/S0014-5793(98)00266-X. PMID 9563500.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Baumann P, Cech TR (May 2001). "Pot1, the putative telomere end-binding protein in fission yeast and humans". Science. 292 (5519): 1171–5. doi:10.1126/science.1060036. PMID 11349150.
- ^ Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Oshumi Y, Jung YK (May 2005). "Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death". J Biol Chem. 280 (21): 20722–9. doi:10.1074/jbc.M413934200. PMID 15778222.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ "Entrez Gene: ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae)".
Further reading
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