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Protein ATP5B PDB 1bmf.png
Aliases ATP5B, ATPMB, ATPSB, HEL-S-271, ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
External IDs MGI: 107801 HomoloGene: 1273 GeneCards: ATP5B
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ATP5B
Genomic location for ATP5B
Band 12q13.3 Start 56,638,175 bp[1]
End 56,646,068 bp[1]
RNA expression pattern
PBB GE ATP5B 201322 at fs.png

PBB GE ATP5B gnf1h05947 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 12: 56.64 – 56.65 Mb Chr 12: 128.08 – 128.09 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

ATP synthase subunit beta, mitochondrial is an enzyme that in humans is encoded by the ATP5B gene.[5][6]


This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110955 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025393 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Neckelmann N, Warner CK, Chung A, Kudoh J, Minoshima S, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Liu JD (Jan 1990). "The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression". Genomics. 5 (4): 829–43. PMID 2687158. doi:10.1016/0888-7543(89)90125-0. 
  6. ^ a b "Entrez Gene: ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide". 

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