ATP6AP1

ATP6AP1
Identifiers
Aliases	ATP6AP1, 16A, ATP6IP1, ATP6S1, Ac45, CF2, VATPS1, XAP-3, XAP3, ATPase H+ transporting accessory protein 1
External IDs	OMIM: 300197; MGI: 109629; HomoloGene: 914; GeneCards: ATP6AP1; OMA:ATP6AP1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,436,516 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,348,327 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; islet of Langerhans; ; stromal cell of endometrium; ; anterior pituitary; ; frontal pole; ; middle frontal gyrus; ; cingulate gyrus; ; Brodmann area 9; ; right lung; ; cerebellar vermis;
	Top expressed in
	superior frontal gyrus; ; calvaria; ; epithelium of stomach; ; cerebellar cortex; ; anterior horn of spinal cord; ; hippocampus proper; ; temporal lobe; ; body of femur; ; amygdala; ; cingulate gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; proton-transporting ATP synthase activity, rotational mechanism; transporter activity; proton-transporting ATPase activity, rotational mechanism; ATP binding;
Cellular component	integral component of membrane; proton-transporting V-type ATPase, V1 domain; membrane; proton-transporting two-sector ATPase complex; endosome membrane; extracellular exosome; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; plasma membrane proton-transporting V-type ATPase complex;
Biological process	insulin receptor signaling pathway; transferrin transport; pH reduction; ion transport; positive regulation of bone resorption; positive regulation of osteoclast development; establishment of organelle localization; ion transmembrane transport; positive regulation of osteoblast differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of exocytosis; cellular iron ion homeostasis; cellular response to increased oxygen levels; transport; regulation of cellular pH; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	537
	54411
	ENSG00000071553
	ENSMUSG00000019087
	Q15904
	Q9R1Q9
	NM_001183
	NM_018794; NM_001358375; NM_001358380
	NP_001174
	NP_061264; NP_001345304; NP_001345309
	Wikidata
View/Edit Human	View/Edit Mouse

The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000071553 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019087 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen EY, Zollo M, Mazzarella R, Ciccodicola A, Chen CN, Zuo L, Heiner C, Burough F, Repetto M, Schlessinger D, D'Urso M (Jun 1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum Mol Genet. 5 (5): 659–68. doi:10.1093/hmg/5.5.659. PMID 8733135.
^ Sedlacek Z, Korn B, Konecki DS, Siebenhaar R, Coy JF, Kioschis P, Poustka A (Feb 1994). "Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection". Hum Mol Genet. 2 (11): 1865–9. doi:10.1093/hmg/2.11.1865. PMID 8281148.
^ "Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1".

External links

Human ATP6AP1 genome location and ATP6AP1 gene details page in the UCSC Genome Browser.

References

External links

Further reading