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Historic Amerindian settlements existed at Tiger Island, Taurakuli and Doctor Ho Landing. The largest Arawak settlement was Abary village in the upper Abary River, which unfortunately now lies under the reservoir created by the Mahaica-Mahaicony-Abary (MMA) project in the 1970s.
In 1672, under an arrangement between the Commander of Essequibo and the Secretary of the Government of Berbice, it was agreed that the Abary River would be the western boundary of the Colony of Berbice.
Farming is the predominant human use of the lower reaches of the river.
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